中药超声雾化治疗季节性过敏性结膜炎的效果及其对泪膜稳定性的影响  

Effect of ultrasonic atomization of traditional Chinese medicine on seasonal allergic conjunctivitis and its influence on tear film stability

作　　者：张光红 莫国艳 黄蓉[1,2] 薛林平 李杜军[1,2] 罗继红[1,2] ZHANG Guanghong;MO Guoyan;HUANG Rong;XUE Linping;LI Dujun;LUO Jihong(Department of Ophthalmology,Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei Province,Wuhan 430061,China;Department of Ophthalmology,Hubei Province Academy of Traditional Chinese Medicine,Hubei Province,Wuhan 430074,China;Key Laboratory of Chinese Medicine Resource and Compound Prescription,Ministry of Education,Hubei University of Chinese Medicine,Hubei Province,Wuhan 430065,China;Ophthalmology Teaching and Research Office,Hubei University of Chinese Medicine,Hubei Province,Wuhan 430065,China)

机构地区：[1]湖北省中医院眼科,湖北武汉430061 [2]湖北省中医药研究院眼科,湖北武汉430074 [3]湖北中医药大学中药资源与中药复方教育部重点实验室,湖北武汉430065 [4]湖北中医药大学眼科教研室,湖北武汉430065

出　　处：《中国医药导报》2021年第3期128-131,150,共5页China Medical Herald

基　　金：湖北省卫生计生委中医药、中西医结合科研项目(鄂卫生计生通〔2017〕20号);湖北省中医院“五专”建设项目眼科(聚星障)(鄂中医院字〔2018〕64号)。

摘　　要：目的观察中药超声雾化治疗季节性过敏性结膜炎(SAC)的临床效果及其对泪膜稳定性的影响。方法采用前瞻随机对照研究法,选取2018年10月—2019年9月在湖北省中医院眼科确诊的SAC患者60例(116眼),根据随机数字表法分为对照组30例(59眼),观察组30例(57眼)。两组均使用0.1%盐酸奥洛他定滴眼液点眼治疗,对照组联合生理盐水超声雾化治疗,观察组联合中药超声雾化治疗。连续治疗7 d后,比较两组临床疗效并分析治疗前后患者主观症状评分、体征评分、总评分及泪膜稳定性指标:非侵入性泪膜破裂时间(Nik-BUT)和角膜荧光素染色(FL)评分的变化。结果治疗后,观察组总有效率高于对照组(P<0.05);两组治疗后主观症状评分、体征评分及总评分均较治疗前降低,且观察组低于对照组(P<0.05);两组治疗后Nik-BUT均长于治疗前,FL评分均低于治疗前,且观察组Nik-BUT长于对照组,FL评分低于对照组,差异有统计学意义(P<0.05)。结论中药超声雾化治疗SAC效果显著,可显著改善患者的症状和体征,同时稳定泪膜,预防干眼症的发生,具有较好的临床应用价值。Objective To observe the effect of ultrasonic atomization of traditional Chinese medicine(TCM)on seasonal allergic conjunctivitis(SAC)and its influence on tear film stability.Methods A prospective,randomized,controlled study was conducted from October 2018 to September 2019 in Department of Ophthalmology,Hubei Provincial Hospital of TCM.A total of 60 patients(116 eyes)diagnosed with SAC were selected in the study and divided into two groups according to the random number table method,30 patients(59 eyes)in control group and 30 patients(57 eyes)in observation group.Both groups were treated with 0.1%olopatadine hydrochloride eye drops,while control group was treated with ultrasonic atomization of normal saline and observation group was treated with ultrasonic atomization of TCM.After continuous treatment for seven days,the clinical efficacy of the two groups was compared and the subjective symptom score,sign score,total score and tear film stability indexes before and after treatment were analyzed:noninvasive keratograph tear breakup time(NIk-BUT)and corneal fluorescein staining(FL)score.Results After treatment,total effective rate of observation group was significantly higher than that of control group(P<0.05).After treatment,subjective symptom scores,signs scores and total scores of both groups were lower than those before treatment,and the observation group were lower than those in the control group(P<0.05).After treatment,Nik-BUT in both groups was significantly longer than that before treatment,FL scores in both groups was significantly lower than that before treatment,moreover,Nik-BUT of the observation group was longer than the control group,and FL score was lower than the control group,the differences were statistically significant(P<0.05).Conclusion Ultrasound atomization of TCM can obviously improve the clinical effect of SAC,alleviate the symptoms and signs of patients,stabilize the tear film.It can prevent the occurrence of dry eyes and has good clinical application value.

关 键 词：超声雾化 过敏性结膜炎 季节性 泪膜稳定性 

分 类 号：R771[医药卫生—眼科]