无锡地区儿童脑性瘫痪高危因素调查分析  

Investigation and analysis of high risk factors of cerebral palsy in children in Wuxi area

作　　者：陆莹[1] 刘毅梅[1] 张娜[1] LU Ying;LIU Yimei;ZHANG Na(Department of Child Health and Rehabilitation,Wuxi Children's Hospital Affiliated to Nanjing Medical University,Wuxi 214023,China)

机构地区：[1]南京医科大学附属无锡市儿童医院儿童保健康复科,江苏无锡214023

出　　处：《中国中西医结合儿科学》2021年第1期84-88,共5页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：无锡市青年医学人才项目(QNRC055);无锡市卫生健康委员会面上项目(MS201840)。

摘　　要：目的分析无锡地区小儿脑性瘫痪(简称脑瘫)的相关高危因素,为预防该病的发生提供重要依据。方法选取2017年1月至2019年12月在无锡市儿童医院儿童保健康复科就诊的50例脑瘫患儿作为观察组,按1∶2的比例选取同期在我科体检的健康儿童100例作为对照组。通过询问儿童父母完成问卷调查。调查项目包括儿童性别、母亲生育年龄、孕期是否接触射线、孕期是否用药、孕期是否住新房坐新车、是否工作、吸烟史、饮酒史、流产史、是否保胎、是否服用叶酸、分娩方式、是否有不良情绪、孕期并发症、是否定期产检、胎次、新生儿早产、出生体质量、新生儿窒息、缺血缺氧性脑病、病理性黄疸。对收集的数据进行单因素分析和多因素Logistic回归分析。结果单因素分析显示,母亲生育年龄、是否工作、吸烟史、流产史、是否有不良情绪、胎次、低体质量、新生儿窒息、缺血缺氧性脑病、病理性黄疸是发生小儿脑瘫的危险因素,差异有统计学意义(P<0.05);多因素分析显示,母亲生育年龄、吸烟史、流产史、不良情绪、胎次、早产、低体质量、新生儿窒息、缺血缺氧性脑病是小儿脑瘫发病的独立危险因素。结论小儿脑瘫的发病因素复杂多样,针对常见的发病因素,进行流行病学调查和统计,做好预防性措施,为减少小儿脑瘫的发生提供科学的理论依据。Objective To analyze the relevant risk factors of cerebral palsy in children in Wuxi area,and to provide evidence for preventing the incidence of cerebral palsy.Methods A total of 50 children with cerebral palsy hospitalized in Pediatric Rehabilitation Center of Wuxi Children's Hospital from January 2017 to December 2019 were selected as observation group.Another 100 healthy children undergoing physical examination in our hospital in the same period were selected as control group.A 1∶2 matched case-control study was conducted.Complete the questionnaire by inquiring the parents of the children.The survey items included gender of children,maternal age,radiation contact,drug use during pregnancy,living in new houses or driving new cars,working,smoking history,drinking history,history of abortion,preventing miscarriage,taking folic acid,delivery methods,bad mood,pregnancy complications,regular prenatal examination,preterm birth,birth weight,neonatal asphyxia,hypoxic-ischemic encephalopathy,and pathological jaundice.All data were analyzed with univariate analysis and multivariate Logistic regression analysis.Results Univariate analysis showed that maternal age,working,smoking history,history of abortion,bad mood,number of births,low weight at birth,neonatal asphyxia,hypoxic-ischemic encephalopathy and pathological jaundice were risk for cerebral palsy in children(P<0.05).The multivariate analysis showed that maternal age,smoking history,history of abortion,bad mood,number of births,premature delivery,low weight at birth,neonatal asphyxia and hypoxic-ischemic encephalopathy were the independent risk factors.Conclusion The relevant risk factors of cerebral palsy in children are various.In order to provide scientific theoretical basis for reducing the incidence of cerebral palsy in children,preventive measures are taken and epidemiological investigation and statistics about common risk factors are carried out.

关 键 词：脑性瘫痪 高危因素 儿童 

分 类 号：R742.3[医药卫生—神经病学与精神病学]