TLR4/NF-κB信号通路在调控牙周炎及高尿酸血症及其相互作用的研究进展  

Exploration on the mechanism of interaction between periodontitis and hyperuricemia based on TLR4/NF-κB signaling pathway

作　　者：郭竹玲 汤涵 黄妙 李京平[3] Guo Zhuling;Tang Han;Huang Miao;Li Jingping(School of Stomatology,Hainan Medical University,Haikou 570100,China;Department of Stomatology,The First Affiliated Hospital of Hainan Medical University,Haikou 570102,China;Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincal Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]海南医学院口腔医学院,海口570100 [2]海南医学院第一附属医院口腔科,海口570102 [3]中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2021年第1期58-62,共5页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：海南省科协青年科技英才学术创新计划项目(QCXM201817);海南省人文医学研究基地规划课题[QRYZH201811(YB)];海南省高等学校科学研究重点项目(Hnky2020ZD-19);海南省卫生健康行业科研项目(19A200062)。

摘　　要：牙周炎属口腔常见病,是一种以菌斑为始动因素的感染性疾病。高尿酸血症属于慢性低度炎症性疾病,主要因嘌呤代谢紊乱所致。研究显示,牙周炎和高尿酸血症在临床表现和发病机制上有相关性,二者均可轻度升高外周血中炎症因子表达,使全身处于微炎症状态。目前,临床上对高尿酸血症合并牙周炎患者的联合治疗策略有待改进。本文基于Toll样受体4(TLR4)/核转录因子κB(NF-κB)信号通路探究牙周炎与高尿酸血症互作的发生机制,以期为高尿酸血症合并牙周炎患者的治疗方案提供新思路。Periodontitis is an infectious disease with plaque as the initiating factor.Hyperuricemia is a chronic lowgrade inflammatory disease,mainly due to purine metabolic disorders.Studies have shown a correlation between periodontitis and hyperuricemia in clinical manifestations and pathogenesis.Both of them could increase the expression of inflammatory factors in peripheral blood and make the whole body in micro-inflammation.At present,the clinical treatment strategy for patients with hyperuricemia and periodontitis needs to be improved.Based on the TLR4/NF-κB pathway,this article explores the mechanism of the interaction between periodontitis and hyperuricemia in order to provide new ideas for the treatment of patients with periodontitis and hyperuricemia.

关 键 词：牙周炎 高尿酸血症 TOLL样受体4 核转录因子ΚB 

分 类 号：R781.42[医药卫生—口腔医学] R589.7[医药卫生—临床医学]