干眼药物研究的沿革与展望  

Evolution and outlook of dry eye pharmatheutical research

作　　者：王明武[1] 于莉[2] Mingwu Wang;Yu Li(NeuVision Medical Institute,Department of Ophthalmology and Vision Science,University of Arizona College of Medicine,Tucson 85710,USA;Shenzhen Eye Hospital,Jinan University Affiliated Shenzhen Eye Hospital,Shenzhen Key Laboratory of Ophthalmology,Shenzhen 518004,China)

机构地区：[1]NeuVision医学研究所亚利桑那大学医学院眼科学和视觉科学系,美国亚利桑那州图桑市85710 [2]深圳市眼科医院暨南大学附属深圳眼科医院深圳眼科学重点实验室,518004

出　　处：《中华实验眼科杂志》2021年第2期97-101,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：深圳市科创委自由探索项目(JCYJ20170306140638792);深圳市科创委国际合作项目(GJHZ20180929145202083)。

摘　　要：干眼是一种多因素诱导的眼部常见病和多发病,严重的干眼不但给患者的工作和生活质量带来影响,同时也增加了其他眼疾并发症的风险。由于发病机制比较复杂,治疗周期较长,干眼已成为一个重要的社会公共卫生问题。传统的干眼治疗药物通常可以减轻干眼症状但不能彻底消除干眼症状,因而远远不能满足临床的需要。国内外新上市的抑制T细胞功能的抗炎药物以及促进泪液分泌的干眼药物一定程度上标志着干眼药剂研究的快速进展,但临床上干眼治疗的局面尚未因此明显改善。干眼的治疗仍面临着很大挑战,干眼新药的研发仍有很大空间。对干眼发病机制的深入研究是今后干眼靶向治疗的基础,目前干眼药物研发取得的进展为临床上干眼的治疗方案设计提供了新的选择。眼科医生应密切关注干眼相关的研究进展和干眼药物的作用机制,以更好地服务于广大患者。Dry eye is a common,highly prevalent and multifactorial ocular disease.Severe dry eye not only has a serious impact on the patient's work performance and quality of life,but also increases the risk of other ocular disease complications.Due to its complex pathogenesis and prolonged treatment cycle,dry eye has become an important social and public health problem.Traditional dry eye drugs can usually alleviate,but not completely eliminate,the symptoms of dry eye,and are far from meeting current clinical demands.Newly marketed domestic and foreign anti-inflammatory drugs that inhibit T cell function as well as drugs that promote tear secretion represent,to some extent,the rapid progress of dry eye drug research.Even so,the overall state of clinical dry eye management has not been significantly improved.Dry eye treatment still faces great challenges;a huge gap exists between clinical needs and the development of new drugs.Insightful research on the pathogenesis of dry eye is the basis for identifying new pharmatheutical targets.Progress in the research and development of dry eye drugs brings about new options for treatment strategies.Ophthalmologists should keep updated to the research progress in dry eye and to the mechanism of actions of new drugs in order to better serve dry eye patients.

关 键 词：干眼 环孢素A 他克莫司 Xiidra 氨溴索 全氟己基辛烷 

分 类 号：R777.34[医药卫生—眼科]