活体共聚焦显微镜下睑板腺囊肿患者睑板腺形态分析  

Morphological analysis of meibomian glands in patients with meibomian gland cyst under in vivo confocal microscope

作　　者：蔡建毫[1] 许灿耿 周玲玲[1] 赵子凤 李泽宜[1] 周元升[1] Cai Jianhao;Xu Cangeng;Zhou Lingling;Zhao Zifeng;Li Zeyi;Zhou Yuansheng(Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong,Shantou 515041,China)

机构地区：[1]汕头大学·香港中文大学联合汕头国际眼科中心,汕头515041

出　　处：《中华实验眼科杂志》2021年第2期139-143,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：广东省医学科学技术研究基金项目(A2018449)。

摘　　要：目的分析睑板腺囊肿患者的睑板腺组织在活体共聚焦显微镜(IVCM)下的形态学改变及特点。方法采用横断面研究方法,选取2018年9月至2019年4月在汕头大学·香港中文大学联合汕头国际眼科中心就诊的睑板腺囊肿患者34例34眼以及无睑板腺疾病患者18例18眼分别作为睑板腺囊肿组和对照组。对所有受检者进行眼科常规检查及IVCM检查,IVCM检查指标包括睑板腺开口面积、开口最短径、开口最长径、睑板腺开口附近腺管形态和睑板腺腺泡形态,分别对睑板腺囊肿组与对照组的各项检查指标进行比较和分析。结果睑板腺囊肿组34眼睑板腺开口均呈不规则扩张,其中70.59%(24/34)开口处可见分泌物堆积形成的栓子,但开口边缘均平滑,睑板腺开口长径、短径和面积分别为(148.12±70.16)μm、(114.77±52.38)μm和9239.11(5506.96,24111.36)μm2,较对照组的(59.35±16.78)μm、(41.98±11.77)μm和2094.19(1432.28,2945.65)μm2明显扩大,差异均有统计学意义(t=5.265,P<0.01;t=5.793,P<0.01;Z=8.000,P<0.01)。睑板腺囊肿组中61.76%(21/34)可见靠近睑板腺开口的腺管呈囊样结构扩张,其内伴有性状各异的分泌物积聚,扩张的腺管边缘平整,且与周边腺泡分界清晰。结论IVCM可在活体上观察睑板腺囊肿患者睑板腺形态学微观改变,睑板腺形态改变包括开口明显扩张伴栓子形成、临近开口的腺管呈囊样扩张伴分泌物积聚、边界清晰。Objective To analyze the morphological changes and features of meibomian gland in patients with meibomian gland cyst under in vivo confocal microscope(IVCM).Methods A cross-sectional study was performed.A total of 34 patients(34 eyes)with meibomian gland cysts and 18 control subjects(18 eyes)in the outpatient department without meibomian gland cysts treated in Shantou International Eye Center from September 2018 to April 2019 were included into the meibomian gland cyst group and control group accordingly.All the subjects underwent routine ophthalmologic examination and IVCM examination.IVCM test indicators included the opening area of meibomian gland,the longest diameter and the shortest diameter of meibomian gland opening,the morphology of glandular tube and acinus adjacent to the meibomian gland opening.The measurement indexes of the meibomian gland cyst group and the control group were compared and analyzed.This study followed the Declaration of Helsinki and was approved by the Ethics Committee of Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong(No.EC20171103[6]-P01).Written informed consent was obtained from each patient before examination.Results The opening of the meibomian glands of the 34 subjects in the meibomian gland cyst group were all enlarged irregularly with smooth boundaries,and emboli in the openings were observed in 70.59%(24/34)of patients.The longest diameter,the shortest diameter and the area of meibomian gland openings were(148.12±70.16)μm,(114.77±52.38)μm and 9239.11(5506.96,24111.36)μm2 in the meibomian gland cyst group,respectively,while(59.35±16.78)μm,(41.98±11.77)μm and 2094.19(1432.28,2945.65)μm2 in the control group,respectively.Compared with the control group,the longest diameter and shortest diameter in the meibomian cyst group were longer,and the area of meibomian gland openings in the meibomian cyst group was larger,and the differences were statistically significant(all at P<0.01).Adjacent to the opening,there was cysti

关 键 词：活体共聚焦显微镜 睑板腺囊肿 睑板腺开口 睑板腺形态 

分 类 号：R777.13[医药卫生—眼科]