角膜后弹力膜内皮移植术研究进展  

Advances in Descemet membrane endothelial keratoplasty

作　　者：王玮(综述)[1] 李贵刚[1] Scheffer C.G.Tseng(审校) Wang Wei;Li Guigang;Scheffer C.G.Tseng(Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;R&D Department,Tissue Tech.,Inc.,Ocular Surface Center,and Ocular Surface Research&Education Foundation,Miami,FL,33126,USA)

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,武汉430030 [2]迈阿密眼表研究与教育中心,33126

出　　处：《中华实验眼科杂志》2021年第2期149-153,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金面上项目(82070936);华中科技大学同济医学院研究型临床医师资助计划项目(3011540019);湖北省卫生计生科研基金项目(WJ2017M073);湖北省自然科学基金面上项目(2020CFB647)。

摘　　要：角膜后弹力膜内皮移植术由于具有相对较低的移植排斥率以及较好的视力预后等优势,目前已成为部分发达国家治疗角膜内皮失代偿的主流手术方式,但限于手术难度较高,学习曲线较长,中国人前房偏浅,加之国内角膜内皮病变往往合并有其他较复杂的眼部疾病,目前国内尚未普遍开展这一手术。本文就角膜后弹力膜内皮移植术的手术适应证、供体植片制备(供体选择、制备技巧、植片的可视化)、关键手术技术(植片的植入、展开、固定)、术后并发症(植片脱位、高眼压、排斥反应、角膜内皮细胞密度下降以及失代偿等)以及视力预后等研究进展进行综述。With relatively low rejection rate and better visual prognosis,Descemet membrane endothelial keratoplasty(DMEK)has become the mainstream surgery for the treatment of endothelial dysfunction in some developed countries,but it has not been applied widely in China due to technical difficulties,the long learning curve,shallow anterior chamber of Chinese people,and the fact that domestic corneal endothelial lesions are often accompanied with other complex eye diseases.In this review,the indications,donor graft preparation including donor selection,graft preparation techniques and visualization of graft,key surgical techniques including the implantation,unwrapping and positioning of graft,postoperative complications including graft detachment,high intraocular pressure,rejection,endothelial cell loss,graft survival rate,and visual prognosis of DMEK were reviewed.

关 键 词：角膜后弹力膜内皮移植术 角膜内皮移植术 角膜内皮失代偿 

分 类 号：R779.6[医药卫生—眼科]