Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities  

作　　者：SONG Ning-Ning YANG Lei-Min ZHANG Min-Jie AN Ren-Feng LIU Wei HUANG Xue-Feng 

机构地区：[1]School of Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China [2]Department of Pharmacology,Nanjing Medical University,Nanjing 210029,China

出　　处：《Chinese Journal of Natural Medicines》2021年第1期63-69,共7页中国天然药物（英文版）

摘　　要：Two new triterpenoid saponins,ardisicrenoside R and S(1 and 2),and one new phenylpropanoid glycoside,ardicrephenin(3),along with five known compounds(4-8),were isolated from roots of Ardisia crenata.Their structures were elucidated on the basis of NMR spectroscopic data and chemical methods.Compounds 2-7 were evaluated for their cytotoxic activities against A549,MCF-7,HepG2 and MDA-MB-231 cell lines by MTT assay.Ardicrenin(6)showed significant cytotoxicity,with IC50 values of 1.17±0.01,1.19±0.06,3.52±0.23,and 16.61±1.02μmol·L^(-1),respectively.

关 键 词：Ardisia crenata Triterpenoid saponins Phenylpropanoid glycoside CYTOTOXICITY 

分 类 号：R284.1[医药卫生—中药学]