眼眶成纤维细胞异常脂肪分化与甲状腺相关性眼病关系的研究进展  

Abnormal adipogenesis originated from orbital fibroblasts in thyroid-associated ophthalmopathy

作　　者：冯周琴 邵加庆 叶小珍 Feng Zhouqin;Shao Jiaqing;Ye Xiaozhen(Department of Endocrinology,General Hospital of Eastern Thea-ter Command,the First School of Clinical Medicine,Souhern Medica.l University,Nanjing 210000,China)

机构地区：[1]南方医科大学第一临床医学院东部战区总医院内分泌科,南京210000

出　　处：《国际内分泌代谢杂志》2021年第1期15-19,共5页International Journal of Endocrinology and Metabolism

基　　金：江苏省自然科学基金(BK20180295)。

摘　　要：甲状腺相关性眼病也称为Graves眼病(Graves’ophthalmopathy,GO),是一种发病机制尚未完全阐明,累及眼眶组织的自身免疫炎性疾病。突眼是该病最常见,也是最难缓解的症状,目前认为其主要与透明质酸沉积,眼外肌增粗.脂肪组织重塑等致眼眶内容物增加有关。其中,眼眶内脂肪组织的增多似乎与突眼关系更为紧密。眼眶成纤维细胞(orbital fibroblasts,OF)中的Thy1^(-)亚型可以分化为脂肪细胞。OF具有分化为脂肪细胞的潜能,影响该分化过程的因素可能涉及信号转导通路的调节。综述GO发病过程中OF的脂肪分化异常,深入了解影响ОF分化为脂肪细胞的机制,早期干预该分化过程,为GO治疗提供新的思路和切入点。Thyroid-associated ophthalmopathy,also named Graves’ophthalmopathy(GO),is an au-toimmune inflammatory disease involved in orbital tissue whose pathogenesis has not been fully elucidated.As the most common and difficultly relieved symptom clinically,proptosis is currently believed caused by theincrease of orbital contents,such as hyaluronic acid deposition,extraocular muscle thickening and adiposetissue remodeling.Among them,the expansion of the orbital adipose tissue seems to relate closer to it.Thy1^(-)subtypes in orbital fibroblasts(OF)can differentiate into adipocytes.OF has the potential to differentiate into adipocytes,and the factors affecting the differentiation process may involve in the regulation of signal transduction pathways.Abnormal adipogenesis originated from orbital fibroblasts in GO was reviewed tofurther understand the adipogenic mechanism,and to intervene it at an early stage,so as to provide newideas and new action sites for treating Go.

关 键 词：甲状腺相关性眼病 眼眶成纤维细胞 脂肪分化 

分 类 号：R771.3[医药卫生—眼科] R581[医药卫生—临床医学]