枳实消痞丸与多潘立酮分别联合伊托必利治疗功能性消化不良的疗效及安全性比较  

Comparison of the therapeutic efficacy and safety of Zhishi Xiaopi Pill and domperidone respectively combined with itopride in the treatment of functional dyspepsia

作　　者：赵玉环 潘爱英 ZHAO Yuhuan;PAN Aiying(Department of Gastroenterology,Xiamen Xianyue Hospital,Fujian,Xiamen 361012,China)

机构地区：[1]厦门市仙岳医院消化内科,福建厦门361012

出　　处：《中国医药科学》2021年第1期120-122,共3页China Medicine And Pharmacy

摘　　要：目的比较分析枳实消痞丸与多潘立酮分别联合伊托必利治疗功能性消化不良的临床疗效和安全性。方法选择2018年1月至2019年12月到厦门市仙岳医院就诊的100例功能性消化不良患者为研究对象,根据治疗方案不同分为两组,每组各50例,其中A组采用枳实消痞丸联合伊托必利治疗,B组采用多潘立酮联合伊托必利治疗,比较两组的治疗总有效率、症状改善情况、药物不良反应发生率以及疾病复发率。结果A组治疗总有效率为98.0%,较B组的86.0%明显升高(P<0.05)。治疗前,两组腹痛、腹胀、食欲不振、恶心呕吐、嗳气评分比较,差异无统计学意义(P>0.05),治疗2周后,A组上述各项症状评分显著低于B组(P<0.05)。A组药物不良反应发生率为4.0%,与B组的6.0%比较,差异无统计学意义(P>0.05)。随访6个月,A组疾病复发率为6.0%,显著低于B组的20.0%(P<0.05)。结论与多潘立酮比较,枳实消痞丸联合伊托必利治疗功能性消化不良的效果更好,能够显著减轻患者临床症状,减少疾病复发,且不良反应少,值得推广应用。Objective To compare and analyze the clinical efficacy and safety of Zhishi Xiaopi Pill and domperidone respectively combined with itopride in the treatment of functional dyspepsia.Methods A total of 100 patients with functional dyspepsia admitted to Xiamen Xianyue Hospital from January 2018 to December 2019 were selected as the research objects,and they were divided into group A(n=50)and group B(n=50)according to different treatment schemes.Group A was treated with Zhishi Xiaopi Pill combined with itopride,and group B was treated with domperidone combined with itopride.The total efficacy rate,symptom improvement,adverse drug reaction rate and disease relapse rate of the two groups were compared.Results The total efficacy rate in group A was 98.0%,which was significantly higher than 86.0%in group B(P<0.05).Before treatment,there were no statistically significant differences in scores of abdominal pains,abdominal distension,anorexia,nausea and vomiting and belching between the two groups(P>0.05).After two weeks of treatment,the scores of the above symptoms in group A were significantly lower than those in group B(P<0.05).The incidence of adverse drug reaction rate in group A was 4.0%,in which there was no statistically significant difference between 6.0%in group B(P>0.05).It was shown by a follow-up of 6 months that the disease relapse rate in group A was 6.0%,which was significantly lower than 20.0%in group B(P<0.05).Conclusion Compared with domperidone,Zhishi Xiaopi Pill combined with itopride has a better efficacy on functional dyspepsia,which can significantly alleviate the clinical symptoms of patients and reduce the relapse of diseases,and its adverse reactions are less,which is worthy of promotion and application.

关 键 词：功能性消化不良 伊托必利 多潘立酮 枳实消痞丸 

分 类 号：R573[医药卫生—消化系统]