Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors  

作　　者：Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li 

机构地区：[1]College of Chemistry&Environmental Science,Analytical Chemistry Key Laboratory of Hebei Province,Chemical Biology Key Laboratory of Hebei Province,Hebei University,Baoding,071002,China [2]Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education,Institute of Life Science and Green Development,Hebei University,Baoding,071002,China [3]College of Pharmaceutical Science,Key Laboratory of Pharmaceutical Quality Control of Hebei Province,Hebei University,Baoding,071002,China [4]Beijing Pharmaceutical Group Company Limited,Beijing,100101,China [5]The National Institutes of Pharmaceutical R&D Co.,Ltd.,China Resources Pharmaceutical Group Limited,Beijing,102206,China [6]CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing,100190,China

出　　处：《Nano Research》2021年第3期667-673,共7页纳米研究（英文版）

基　　金：This work was supported by National Natural Science Foundation of China(Nos.21977024,21601046,and 31971304);Advanced Talents Incubation Program of the Hebei University(No.801260201020);Funded by China Postdoctoral Science Foundation(No.2019M650558);Beijing Postdoctoral Research Foundation and Beijing Chaoyang District Postdoctoral Research Fundation.We are grateful to Medical Comprehensive Experimental Center of Hebei University for the animal experiment.

摘　　要：Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor metastases.Therefore,strategies for the eradication of the hypoxic tumor are highly desirable.Photodynamic therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer.Compared to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and resistance.However,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective.Cyanobacteria,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under sunlight.Inspired by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT system.Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.

关 键 词：self-supplying oxygen CYANOBACTERIA hypoxic tumor photodynamic therapy upconversion nanoparticles 

分 类 号：R730.5[医药卫生—肿瘤]