氟哌噻吨美利曲辛片治疗乳腺癌改良根治术后化疗患者焦虑的效果及对应激反应的影响  

Effect of combined therapy with Flupentixol and Melitracen Tablets on stress response of patients after modified radical mastectomy

作　　者：许桂峰 吕京 陈洪杰[3] 高登鹏[3] 冯至真 XU Guifeng;LYU Jing;CHEN Hongjie;GAO Dengpeng;FENG Zhizhen(Department of Oncology, Langfang People's Hospital, Langfang 065099,China;Department of Respiratory, Langfang Third People's Hospital, Langfang 065099,China;Department of General Surgery, Langfang people's Hospital, Langfang 065099,China;The Clinical Medicine College, Hebei Medical University, Shijiazhuang 050017,China)

机构地区：[1]廊坊市人民医院肿瘤科,河北廊坊065099 [2]廊坊市第三人民医院呼吸科,河北廊坊065099 [3]廊坊市人民医院普外科,河北廊坊065099 [4]河北医科大学临床医学院,河北石家庄050017

出　　处：《中国肿瘤外科杂志》2021年第1期86-89,共4页Chinese Journal of Surgical Oncology

基　　金：廊坊市科学技术研究与发展计划项目(2019013018)。

摘　　要：目的探讨氟哌噻吨美利曲辛片(黛力新)治疗乳腺癌改良根治术后化疗患者焦虑的效果及对应激反应的影响。方法选择2018年9月至2020年1月廊坊市人民医院收治的乳腺癌改良根治术后化疗患者96例作为研究对象,根据时间点分为对照组(n=48例,2018年9月至2019年4月)和观察组(n=48例,2019年5月至2020年1月)。对照组给予心理干预治疗,观察组给予心理治疗与黛力新联合疗法,比较两组患者抑郁自评量表(SDS)、焦虑自评量表(SAS)评分、应激反应及生活质量。结果两组治疗后2个月评估,心理评分均低于治疗前(P<0.05);观察组SDS、SAS量表评分低于对照组(P<0.05),应激反应一氧化氮(NO)、血清皮质醇(Cor)水平低于对照组(P<0.05),超氧化物歧化酶(SOD)水平高于对照组(P<0.05),生理、心理、独立性、环境及社会关系领域评分均高于对照组(P<0.05)。结论心理治疗联合黛力新口服能降低乳腺癌改良根治术后化疗患者心理焦虑及应激反应,提高其化疗后生活质量。Objective To investigate the effect of flupentixol and melitroxine tablets(Dailysine)in the treatment of anxiety in patients with breast cancer after modified radical mastectomy and its influence on stress response.Methods Ninety-six patients undergoing chemotherapy after modified radical mastectomy for breast cancer admitted to Langfang People's Hospital from September,2018 to January,2020 were selected as subjects,and were divided into control groups(n=48 cases,September 2018 to April,2019)and the observation group(n=48 cases,May,2019 to January,2020).The control group was given psychological intervention treatment,and the observation group was given psychotherapy combined with Deanxit combined therapy.The two groups were compared with the self-rating depression scale(SDS),self-rating anxiety scale(SAS)scores,stress response and quality of life.Results The psychological scores of the two groups were lower than that before treatment after treatment(P<0.05);the SDS and SAS scales of the observation group were lower than those of the control group after treatment(P<0.05);The level of nitric oxide(NO)and serum cortisol(Cor)in the aggravated reaction was lower than that of the control group(P<0.05);the superoxide dismutase(SOD)level of the observation group was higher than that of the control group after treatment(P<0.05),the scores of physiology,psychology,independence,environment and social relations were higher than those of the control group(P<0.05).Conclusions Deanxit combined therapy can reduce the psychological fluctuation and stress response of patients after modified radical mastectomy for breast cancer and improve the quality of life after chemotherapy.

关 键 词：氟哌噻吨美利曲辛片 联合疗法 心理干预 乳腺癌改良根治术 术后化疗 焦虑症 应激反应 

分 类 号：R73[医药卫生—肿瘤]