晚期糖基化终末产物受体及其配体在骨代谢疾病中作用的研究进展  

Research progress of receptor for advanced glycation end products and its ligands in metabolic bone diseases

作　　者：刘晓辉(综述) 崔舜(审校)[1] LIU Xiao-hui;CUI Shun(Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China)

机构地区：[1]华中科技大学同济医学院附属协和医院风湿免疫科,武汉430022

出　　处：《中国临床新医学》2021年第2期201-205,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:81671560)。

摘　　要：晚期糖基化终末产物受体(RAGE)是具有多种配体的免疫球蛋白超家族成员,参与多种疾病的发病机制,包括神经退行性疾病阿尔茨海默病、糖尿病并发症以及多种与衰老、炎症相关的疾病,在调节先天免疫反应中起着关键作用。RAGE及其配体不仅是多种炎症反应的重要细胞因子,而且在骨髓间充质干细胞、成骨细胞及破骨细胞均表达RAGE。近年来,关于RAGE及其配体在成骨、破骨细胞增殖分化过程,软骨细胞发育过程以及骨重塑中所起到的作用被逐渐认识。该文主要综述了RAGE及其配体对骨代谢的影响及作用机制,以揭示慢性炎症相关的骨丢失及骨重塑的调控机制,为骨代谢疾病的治疗提供新思路。Receptor for advanced glycation end products(RAGE),a member of the immunoglobulin superfamily transmembrane proteins with multiple ligands,is involved in the pathogenesis of a variety of diseases,including Alzheimer′s disease a neurodegenerative disease,diabetes complications,and many diseases related to aging and inflammation.RAGE also plays a key role in regulating the innate immune response.RAGE and its ligands are not only important factors in various inflammatory reactions but also express RAGE in bone marrow mesenchymal stem cells,osteoblasts and osteoclasts.In recent years,the role of RAGE and its ligands in the process of osteoblast and osteoclast proliferations and differentiations,chondrocyte development and bone remodeling has been gradually recognized.In this paper,we mainly review the effects of RAGE and its ligands on bone metabolism and the mechanisms,in order to reveal the regulatory mechanisms of chronic inflammation-related bone loss and bone remodeling,and provide new ideas for the treatment of metabolic bone diseases.

关 键 词：晚期糖基化终末产物受体 成骨细胞 破骨细胞 骨代谢疾病 

分 类 号：R684.3[医药卫生—骨科学]