奥美拉唑联合生长抑素治疗肝硬化并上消化道大出血的临床疗效  

Clinical efficacy of omeprazole combined with somatostatin in the treatment of liver cirrhosis complicated with upper gastrointestinal hemorrhage

作　　者：王静 WANG Jing(Dalian Fourth People's Hospital,Dalian 116031,China)

机构地区：[1]大连市第四人民医院,116031

出　　处：《中国实用医药》2021年第4期11-13,共3页China Practical Medicine

摘　　要：目的评价分析肝硬化并上消化道大出血采取奥美拉唑联合生长抑素治疗的临床效果。方法 90例肝硬化并上消化道大出血患者,以随机数字表法分为常规组和实验组,每组45例。两组患者均行一般对症治疗,常规组采用奥美拉唑治疗,实验组采用奥美拉唑联合生长抑素治疗。比较两组临床疗效、各临床指标(住院天数、止血时间、输血量、再次出血率)、不良反应发生情况。结果实验组临床总有效率95.56%明显高于常规组的82.22%,差异具有统计学意义(χ^(2)=4.0500, P=0.0442<0.05)。实验组住院天数、止血时间均短于常规组,输血量少于常规组,再次出血率低于常规组,差异具有统计学意义(P<0.05)。实验组患者不良反应发生率8.89%明显低于常规组的28.89%,差异具有统计学意义(P<0.05)。结论肝硬化并上消化道大出血采取奥美拉唑联合生长抑素治疗效果良好,可减少患者出血量及不良反应,对其预后发挥促进作用。Objective To evaluate and analyze the clinical effect of omeprazole combined with somatostatin in the treatment of liver cirrhosis complicated with upper gastrointestinal hemorrhage.Methods A total of 90 cases of liver cirrhosis complicated with upper gastrointestinal hemorrhage were divided into conventional group and experimental group according to random numerical table,with 45 cases in each group.Both groups received general symptomatic treatment,the conventional group was treated with omeprazole,and the experimental group was treated with omeprazole combined with somatostatin.The clinical efficacy,clinical indicators(hospitalization time,hemostasis time,blood transfusion volume,rehemorrhage rate)and occurrence of adverse reactions were compared between the two groups.Results The total clinical effective rate 95.56%of the experimental group was obviously higher than 82.22%of the conventional group,and the difference was statistically significant(χ^(2)=4.0500,P=0.0442<0.05).The hospitalization time and hemostasis time of the experimental group were shorter than those of the conventional group,blood transfusion volume was less than that of conventional group,and rehemorrhage rate was lower than that of the conventional group.The difference was statistically significant(P<0.05).The incidence of adverse reactions 8.89%of the experimental group was obviously lower than 28.89%of the conventional group,and the difference was statistically significant(P<0.05).Conclusion Omeprazole combined with somatostatin has good effect in the treatment of liver cirrhosis complicated with upper gastrointestinal hemorrhage,which can reduce blood loss and adverse reactions,thus promoting the prognosis of the patients.

关 键 词：肝硬化 上消化道大出血 奥美拉唑 生长抑素 

分 类 号：R575.2[医药卫生—消化系统] R573.2[医药卫生—内科学]