主观认知下降患者静息态磁共振局部一致性与功能连接研究  

The study on the combined regional homogeneity and functional connectivity of resting-state magnetic resonance in patients with subjective cognitive decline

作　　者：汪腾龙 赵幸福[2] 吴越[2] 程灶火[2] 周振和[2] 王栋[2] 陆丽萍 吴雪桉 韩胜楠 Wang Tenglong;Zhao Xingfu;Wu Yue;Cheng Zaohuo;Zhou Zhenhe;Wang Dong;Lu Liping;Wu Xuean;Han Shengnan(Wannan Medical College,School of Humanities and Management,Wuhu 241002,China;Wuxi Mental Center,Wuxi 214151,China)

机构地区：[1]皖南医学院人文与管理学院,芜湖241002 [2]无锡市精神卫生中心,214151

出　　处：《中华老年医学杂志》2021年第1期72-75,共4页Chinese Journal of Geriatrics

基　　金：江苏省社会发展--面上项目(BE2017624);江苏省社会发展重点项目(BE2015615);苏州科教兴卫青年项目(KJXW2019048)。

摘　　要：目的通过联合应用局部一致性(ReHo)和功能连接(FC)对主观认知下降(SCD)患者进行研究,探讨静息态下SCD的机制。方法对25例SCD及30例性别、受教育年限、民族等相匹配的健康对照组进行静息态功能磁共振(RS-fMRI)扫描,应用DPARSFA2.3和SPM8软件分析筛选SCD组ReHo值异常脑区,以后扣带回/楔前叶作为种子点行全脑FC分析。结果与健康对照组相比,SCD组右侧枕中回、左侧楔前叶ReHo值升高[体素水平(Voxel)水平,Alphasim校正,P<0.05];右侧颞下回、右侧眶部额下回、左右侧丘脑ReHo值减低(Voxel水平,Alphasim校正,P<0.05);后扣带回/楔前叶与全脑的功能连接发现Cerebelum_Crus2_R连接增强(Voxel水平,Alphasim校正,P<0.05),而与右侧眶部额下回、左侧颞下回、颞极功能连接强度低于健康对照组(Voxel水平,Alphasim校正,P<0.05)。结论默认网络(DMN)可能在SCD的机制中发挥着重要作用,并且脑区异常可能最早发生于后扣带回/楔前叶。Objective To investigate the mechanism of subjective cognitive decline(SCD)in resting-state by using regional homogeneity(ReHo)and functional connectivity(FC)in SCD patients.Methods Resting-state functional magnetic resonance imaging(RS-fMRI)was performed in 25 SCD patients and 30 normal controls matched by sex,education and nationality.DPARSFA2.3 and SPM8 software were used to analyze and screen the brain areas with abnormal ReHo values in SCD group,with the posterior cingulated(PCC)/paruneus as seed points for whole-brain FC analysis.Results Compared with the normal control group,the SCD group showed that ReHo values of right occipital gyrus and left precuneus were increased,and ReHo values of right inferior temporal gyrus,right orbital inferior frontal gyrus and bilateral thalamus were decreased(Voxel level,Alphasim correction,P<0.05).Using PCC/precuneus as seed voxels,the whole brain functional connectivity analysis showed that the functional connectivity with cerebelum Crus 2 R was increased,and the functional connectivity with right orbital inferior frontal gyrus,left inferior temporal gyrus and temporal pole was reduced(Voxel level,Alphasim correction,all P<0.05).Conclusions Default mode network may play an important role in the mechanism of SCD,and abnormalities in brain areas may first occur in PCC/precuneus.

关 键 词：主观认知下降 磁共振成像 

分 类 号：R749.16[医药卫生—神经病学与精神病学]