基于纳米生物材料的肿瘤乏氧调控与放疗增效研究进展  

Recent Progress in Nano-biomaterials for Tumor Hypoxia Relief and Enhanced Cancer Radiotherapy

作　　者：赵琪 刘庄[1] ZHAO Qi;LIU Zhuang(Institute of Functional Nano&Soft Materials(FUNSOM),Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学功能纳米与软物质研究院,苏州215123

出　　处：《肿瘤防治研究》2021年第2期109-114,共6页Cancer Research on Prevention and Treatment

基　　金：中国科技部国家研究项目(2016YFA0201 200);国家自然科学基金(21927803,52032008);江苏省社会发展项目(BE2019658)。

摘　　要：放射治疗是临床肿瘤治疗常用的一种治疗策略,包括将放射性核素注射或植入体内的核素内放疗以及利用外界的射线(如X射线)对肿瘤部位进行照射的外照射放疗两大类。由于氧分子在电离辐射杀伤肿瘤细胞的过程中发挥着重要的作用,而实体肿瘤内部却普遍存在乏氧的微环境,肿瘤乏氧是导致其对放疗耐受的重要原因之一。近年来,随着生物材料和纳米技术的发展,一系列有效调控和逆转肿瘤乏氧微环境的技术被报道。本文将介绍近年来发展的基于纳米生物材料的肿瘤乏氧调控策略及其在放疗增敏中的应用,并对该类技术未来的临床应用进行展望和讨论。Radiation therapy is an extensively applied cancer treatment methods in clinic.Radiation therapy can be conducted by either administrating/implanting radioactive isotope agents into the patients to irradiate tumors from inside,or using external beams(e.g.X-ray beams)to irradiate the tumor from the outside.It is well known that oxygen molecules play an important role in enhancing radiation-induced cancer cell killing.However,as most of solid tumors possess hypoxic tumor microenvironment,the tumor hypoxia is well recognized as one of important reasons that lead to the resistance of tumors to radiation therapies.In recent years,owing to the rapid development of biomaterials and nanotechnology,many different strategies have been reported to effectively modulate and reverse the hypoxic tumor microenvironment.In this article,we will summarize various types of nano-biomaterials for tumor hypoxia relief and their application in radiotherapy sensibilization,as well as the future clinical translation.

关 键 词：纳米技术 生物材料 肿瘤乏氧 肿瘤放疗 

分 类 号：Q819[生物学—生物工程] R730.55[医药卫生—肿瘤]