Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc  

作　　者：Wen-Min Fan Dan Luo Jun-Zheng Zhang Dan Wang Jie Shen 

机构地区：[1]Department of Entomology and MOA Lab for Pest Monitoring and Green Control,China Agricultural University,Beijing,China

出　　处：《Insect Science》2021年第1期63-76,共14页昆虫科学（英文版）

基　　金：by the National Natural Science Foundation of China(NSFC31872293 and 31872295).

摘　　要：The Decapentaplegic(Dpp)and Wingless(Wg)signal pathways play important roles in numerous biological processes in Drosophila.The Drosophila vestigial(vg)gene is selectively required for wing imaginal disc cell proliferation,which is essential for the formation of the adult wing and halter structures,and is regulated by Dpp and Wg signaling.Using a Drosophila invasion model of wing epithelium,we showed herein that inhibition of Dpp or Wg signaling promoted cells to migrate across the cell lineage restrictive anterior/posterior(A/P)compartment boundary.Being downstream of both Dpp and Wg signaling,vg can block cell migration induced by loss of either pathway.In addition,suppression of vg is sufficient to induce cell migration across the A/P boundary.Transcriptomic analysis revealed potential downstream genes involved in the cell migration after suppressing vg in the wing disc.We further demonstrated that the c-Jun N-terminal kinase(JNK)signaling promoted cell migration induced by vg suppression by upregulating Caspase activity.Taken together,our results revealed the requirement ofVg for suppressing cell migration and clarified how developmental signals collaborate to stabilize cells along the compartment boundary.

关 键 词：CASPASE cell migration Dpp Drosophila wing disc JNK VESTIGIAL Wg 

分 类 号：Q96[生物学—昆虫学]