以苯丙氨酸为例刍议芳香族氨基酸的生物合成机理  

Discussion on the Biosynthesis Mechanism of Aromatic Amino Acids: Taking Phenylalanine as Example

作　　者：蒋振雄 王志鹏[3,4,5] 马新雨 颜惠娟 缑允梓 尹晟 王鹏 JIANG Zhen-Xiong;WANG Zhipeng A;MA Xin-Yu;YAN Hui-Juan;GOU Yun-Zi;YIN Sheng;WANG Peng(Department of Biology,Texas A&M University,Texas 77840,USA;Plant Pathology&Microbiology Department,Texas A&M University,Texas 77840,USA;Department of Chemistry,Tsinghua University,Beijing 100084,China;Department of Chemistry,Texas A&M University,College Station,Texas 77840,USA;Division of Genetics,Department of Medicine,Brigham and Women’s Hospital,Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,Boston,MA 02115,USA;Nutrition/Metabolism Laboratory,Department of Surgery,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA 02138,USA;Department of Burn Surgery,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China)

机构地区：[1]Department of Biology,Texas A&M University,Texas 77840,USA [2]Plant Pathology&Microbiology Department,Texas A&M University,Texas 77840,USA [3]清华大学化学系,北京100084 [4]Department of Chemistry,Texas A&M University,College Station,Texas 77840,USA [5]Division of Genetics,Department of Medicine,Brigham and Women’s Hospital,Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,Boston,MA 02115,USA [6]Nutrition/Metabolism Laboratory,Department of Surgery,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA 02138,USA [7]中山大学附属第一医院烧伤外科,广东广州510080

出　　处：《化学教育（中英文）》2021年第2期71-79,共9页Chinese Journal of Chemical Education

摘　　要：从磷酸烯醇式丙酮酸和4-磷酸赤藓糖为始探讨了3种芳香族氨基酸合成代谢共享的分支酸合成途径,并以苯丙氨酸为例从多学科角度讨论分析其合成代谢的独特性。通过多学科角度展示了生物体内不同代谢路径之间的关联及相似性,旨在展示一种教学新模式,帮助学生建立起跨学科内容的学习及归纳方法。This paper starts from phosphoenolpyruvic acid and erythrose 4-phosphate for a detailed introduction on the synthesis of chorismate, the common substrate shared by three aromatic amino acids, followed by the analysis on the uniqueness of the phenylalanine biosynthesis as an example from different subject’s perspective. Through comparing and contrasting the discrepancies and similarities of different metabolic pathways from different angles, this manuscript is aimed to work as a compass helping students to establish the methodology on learning interdisciplinary knowledge.

关 键 词：苯丙氨酸 芳香氨基酸 生物化学 必需氨基酸 

分 类 号：O625.636-4[理学—有机化学] G642[理学—化学]