血管内介入栓塞治疗急性破裂期后循环动脉瘤的临床研究及对血清NSE、S100B的影响  

Clinical effects of endovascular embolization on treatment of acute ruptured posterior circulation aneurysms and corresponding serum levels of neuron-specific enolase and S100B protein

作　　者：朱宗锦 刘保华 袁璞 聂文臣 徐瀚 刘厚强 ZHU Zongjin;LIU Baohua;YAN Pu;NIE Wenchen;XU Han;LIU Houqiang(Department of Neurosurgery,Suqian Hospital Affiliated to Xuzhou Medical University,Suqian 223800,China)

机构地区：[1]徐州医科大学附属宿迁医院神经外科,江苏宿迁223800

出　　处：《中国急救复苏与灾害医学杂志》2021年第2期165-168,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：江苏省自然科学基金面上项目(编号:SK20161140)。

摘　　要：目的探讨血管内介入栓塞治疗急性破裂期后循环动脉瘤的临床价值。方法选取2016年3月-2020年3月急性破裂期后循环动脉瘤的80例患者,并根据随机数字表法分为对照组和观察组,每组各40例,其中对照组患者采取开颅手术治疗,观察组采取血管内介入栓塞治疗。对两组患者手术时间、住院时间以及住院费用一般情况进行比较,观察两组患者围术期NSE、S100B指标含量,对比两组患者手术前后Hunt-Hess分级,并比较两组患者术后并发症发生率以及预后GOS评分差异。结果观察组在手术时间、住院时间方面均优于对照组(P<0.05);对照组住院费用低于观察组(P<0.05);观察组手术后6h、手术后24 h两个时间段NSE、S100B指标含量均低于对照组(P<0.05);两组患者手术前后Hunt-Hess分级、术后并发症发生率、GOS预后评分均无差异(P>0.05)。结论介入治疗急性破裂期后循环动脉瘤可缩短手术时间,减少神经功能损伤,有利于患者术后康复。Objective To investigate the efficacy of endovascular embolization in the treatment of acute ruptured posteri-or circulation aneurysms.Methods 80 demographically and clinically matched patients with post rupture circulation an-eurysm were randomLy appointed lo 2 equal groups:control group lreated by craniotomy and observation group treated by endovascular embolization.The general situation of operation time,hospitalization time and hospitalization cost of the two groups were compared.Peripheral blood samples were ollcted before operation,and 6h and 24h after operation to test the levels of neuron-speific enolase(NSE)and S100B protein.By ELISA.The postoperative complication rate and Hunt--Hess grade were recorded??months after operation.Three months after operation,follow-up was performed by phone call to obtain the score of Glasgow Outcome Scale(GOS).Results The operation time and hospitalization time of the observation group were(2.89±0.41)h and(11.23±2.08)d respectively,both significantly shorter than those of the con-trol group[(4.01±0.36)h and(17.18±2.36)d respectively,both P<0.05],and the cost of hospitalization of the observation group was(102000±7200)yuan,significantly higher than that of the control group[(61000±6400)yuan,P<0.05].The serum levels of NSE and S100B protein of the observation group was both lower than those of the control group(both P<0.05).There were no differences in the Hunt Hess grade,postoperative complication rate,and GOS score between the two groups(all P>0.05).Conclusion Interventional treatment of posterior circulation aneurysms in acute rupture period shortens the operation time,reduces the damage of nerve function,and helps the patients recover after operation.

关 键 词：介入治疗 急性破裂期后循环动脉瘤 开颅手术 

分 类 号：R732.21[医药卫生—肿瘤]