SARS-CoV-2与SARS-CoV:病原学、流行病学、临床与病理  

SARS-CoV-2 and SARS-CoV:Etiology,Epidemiology,Clinical Manifestation and Pathology

作　　者：杨逸成 肖志强 叶凯雁 郎欣月 蔡雯念 肖维威 赵卫 YANG Yicheng;XIAO Zhiqiang;YE Kaiyan;LANG Xinyue;CAI Wennian;XIAO Weiwei;ZHAO Wei(Guangdong Provincial Key Laboratory of Tropical Disease Research,School of Public Health,Southern Medical University,Guangzhou 510515,China;Fuwai Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,100037,China;Department of Clinical Medicine,Zhengzhou University,Zhengzhou 450001,China;Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200120,China)

机构地区：[1]南方医科大学公共卫生学院,广东省热带病研究重点实验室,广州510515 [2]中国医学科学院北京协和医学院阜外医院,北京100037 [3]郑州大学医学院临床医学系,郑州450001 [4]上海交通大学附属仁济医院,上海200120

出　　处：《病毒学报》2021年第1期211-218,共8页Chinese Journal of Virology

基　　金：广东省科技攻关项目(项目号:2018B020207006),题目:广东省疾病防控科技协同创新中心;广州市科技攻关项目(项目号:201803040006),题目:广州登革热流行地病原学、媒介控制与临床救治研究;阳江市科技攻关项目(项目号:2019010),题目:阳江市人民医院分子医学重点实验室。

摘　　要：2019年12月在武汉暴发了由SARS-CoV-2感染引起的新型冠状病毒肺炎(Coronavirus disease 2019,COVID-19),并迅速扩散至全国。SARS-CoV-2和SARS冠状病毒(SARS-CoV)都属于套式病毒目、冠状病毒科、冠状病毒属中的SARS相关冠状病毒种,本文总结了两者在来源、病毒结构、流行病学、临床表现和病理学特征等方面的差异,以期更全面认识SARS-CoV和SARS-CoV-2,为COVID-19的防治研究提供帮助。Coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 infection broke out in Wuhan,Hubei Province,China,in December 2019 and spread rapidly across China.COVID-19 was declared a pandemic by the World Health Organization on 11 March 2020.SARS-CoV-2 and SARS-CoV belong to subfamily Coronavirinae in the family Coronaviridae of the order Nidovirales,and they are classified as the"SARS-like species"even though they belong to different clusters.The structure,epidemiology characteristics,clinical manifestations and pathologic characteristics between SARS-CoV-2 and SARS-CoV are also different.The differences between SARS-CoV-2 and SARS-CoV are summarized in this review to aid understanding and control of SARS-CoV-2 infection.

关 键 词：新型冠状病毒(SARS-CoV-2) COVID-19 SARS-COV 防治 

分 类 号：R373.1[医药卫生—病原生物学] R512.99[医药卫生—基础医学]