中国9个长寿地区65岁及以上人群中性粒细胞与淋巴细胞比值与抑郁症状的关联研究  

Association of neutrophil-to-lymphocyte ratio with depressive symptoms among older adults aged 65 years and above in 9 longevity areas of China

作　　者：张晓畅 吕跃斌 周锦辉 陈晨[1] 李成橙[1] 蔡军芳[1] 曹兆进[1] 赵峰[1] 刘迎春[1] 顾珩[1] 路凤 施小明[1] Zhang Xiaochang;Lyu Yuebin;Zhou Jinhui;Chen Chen;Li Chengcheng;Cai Junfang;Cao Zhaojin;Zhao Feng;Liu Yingchun;Gu Heng;Lu Feng;Shi Xiaoming(China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;Beijing Municipal Health Commission Information Center/Beijing Municipal Health Commission Policy Research Center,Beijing 100034,China)

机构地区：[1]中国疾病预防控制中心环境与人群健康重点实验室,中国疾病预防控制中心环境与健康相关产品安全所,北京100021 [2]北京市卫生健康委信息中心,北京市卫生健康委政策研究中心,100034

出　　处：《中华预防医学杂志》2021年第1期25-30,共6页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(82025030,81941023,81872707);国家重点研发计划(2018YFC2000400)

摘　　要：目的分析中国9个长寿地区65岁及以上人群中性粒细胞与淋巴细胞比值(NLR)与抑郁风险的关联。方法研究对象来自2017-2018年在我国9个长寿地区开展的“老年健康生物标志物队列研究”,最终将2018名中性粒细胞计数、淋巴细胞计数和抑郁状态数据完整的65岁及以上人群纳入研究。通过问卷调查和体格检测,收集调查对象的人口学特征、行为生活方式、健康状况等信息;同时收集调查对象的空腹静脉血以检测淋巴细胞、中性粒细胞等水平。根据调查对象NLR的四分位数将对象分为Q1、Q2、Q3、Q4四组,采用logistic回归模型分析NLR与抑郁症状的关联。结果2018名调查对象年龄为(82.60±10.73)岁,其中男性1032名(51.14%),抑郁症状检出率19.33%(390名)。多因素logistic回归模型分析结果显示,调整相关混杂因素后,与NLR的Q1组相比,Q2、Q3、Q4组检出抑郁症状的风险较高[OR(95%CI)值分别为1.47(0.99~2.19)、1.67(1.13~2.47)和1.95(1.32~2.89)]。结论中国9个长寿地区65岁及以上老年人NLR水平与抑郁症状患病风险存在正向关联。Objective To investigate the relationship between the neutrophil-to-lymphocyte ratio(NLR)and the risk of depression symptoms among older adults aged 65 and above in 9 longevity areas of China.Methods Data was collected in 9 longevity areas of China from Healthy Aging and Biomarkers Cohort Study(HABCS)conducted between 2017 and 2018.Finally,2018 elderly aged 65 years and above with complete information on neutrophil count,lymphocyte count and depressive symptoms were included in this study.Information on demographic characteristics,lifestyle,and health status was collected through questionnaire and physical examination.Complete blood counts which included lymphocytes and neutrophils were obtained by testing venous blood samples.Participants were divided into four groups by the quartile of NLR level,i.e.Q1,Q2,Q3,Q4.Logistic regression model was applied to analyze the association of NLR with depression symptoms.Results Among 2018 older adults,the mean(±SD)age was 82.6(±10.73),1032(51.14%)were male,390(19.33%)were detected with depressive symptoms.Compared with participants of NLR in the 1st quartile,the OR(95%CI)of risk for depressive symptoms was 1.47(0.99,2.19),1.67(1.13,2.47)and 1.95(1.32,2.89),respectively.Conclusion Increased NLR level is significantly related to depressive symptoms among elderly aged 65 years and above in 9 longevity areas in China.

关 键 词：老年人 抑郁症 横断面研究 中性粒细胞与淋巴细胞比值 

分 类 号：R749.4[医药卫生—神经病学与精神病学]