Voxel-based analysis of brain microstructural diffusion indices changes in Parkinson disease with freezing of gait  

作　　者：Jing-Wu Chen Fa-Ze Mai Yong-Zhe Yang Wan-Qun Yang Li-Juan Wang Kun Nie Biao Huang 

机构地区：[1]Department of Radiology,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510260,China [2]Department of Radiology,Hainan General Hospital,Haikou,Hainan 570311,China [3]School of Medicine,South China University of Technology,Guangzhou,Guangdong 510006,China [4]Department of Radiology,Guangdong Academy of Medical Sciences,Guangdong Provincial People's Hospital,Guangzhou,Guangdong 510080,China [5]Department of Neurology,Guangdong Academy of Medical Sciences,Guangdong Provincial People’s Hospital,Guangzhou,Guangdong 510080,China

出　　处：《Chinese Medical Journal》2021年第2期249-251,共3页中华医学杂志（英文版）

基　　金：supported by grants from the Key R&D Program of Guangdong Province,China(No.2018B030339001);the National Natural Science Foundation of China(No.81671275)。

摘　　要：To the Editor:Freezing of gait(FOG)is a common disabling movement disorder in Parkinson disease(PD),affecting approximately 50%to 80%of PD patients in their late state.FOG can cause the patients to fall easily,seriously affects their quality of life and exerts both economic and emotional burdens.Unlike the common motor symptoms of PD(such as bradykinesia,tremor,or rigidity),FOG is seldom improved by dopaminergic medication therapy or deep brain stimulation.Moreover,FOG may be resistant to(or even worsened by)levodopa.[1]However,cognitive training has showed it can reduce the severity of FOG.[2]These findings imply that FOG may be caused not only by motor impairment but also by cognitive impairment.It is reasonable to hypothesize that FOG+patients have impaired cognitive function and that the diffusion indices of the cerebral territories’microstructures associated with cognition are altered.To test this hypothesis,we applied whole-brain voxel-based analysis(VBA),a fully automated whole-brain analysis that uses voxel-wise statistics on diffusion metrics,to investigate the diffusion indices of brain microstructures changes in FOG+patients,PD patients without FOG(FOG-patients),and healthy controls(HCs).

关 键 词：IMPAIRED indices DIFFUSION 

分 类 号：R742.5[医药卫生—神经病学与精神病学]