低剂量多西他赛周疗同步放疗治疗局部晚期食管癌的疗效与安全性分析  

Efficacy and safety of low-dose docetaxel weekly synchronous radiotherapy in the treatment of locally advanced esophageal cancer

作　　者：李玉[1] 耿晓萌 李文文 孙宁华 LI Yu;GENG Xiaomeng;LI Wenwen;SUN Ninghua(Tai'an City Cancer Prevention Hospital,Shandong Tai'an 271000,China;Tai'an City Central Hospital,Shandong Tai'an 271000,China;Tai'an City Cares Hospital,Shandong Tai'an 271000,China)

机构地区：[1]泰安市肿瘤防治院,山东泰安271000 [2]泰安市中心医院,山东泰安271000 [3]泰安市优抚医院,山东泰安271000

出　　处：《现代肿瘤医学》2021年第5期787-789,共3页Journal of Modern Oncology

摘　　要：目的:探讨单纯放疗与联合低剂量多西他赛周疗同步治疗局部晚期食管癌的近期疗效与风险比较。方法:研究对象是选自2015年01月至2018年08月收治的非手术治疗的64例食管癌患者,随机分为两组:实验组(低剂量多西他赛周疗同步放疗,32例)及对照组(单纯放疗,32例),比较两组患者的近期疗效及不良反应。结果:实验组的治疗有效率为81.25%,对照组的治疗有效率为56.25%,实验组明显高于对照组,两组差异有统计学意义(P<0.05)。实验组的骨髓抑制(白细胞降低、血小板降低)发生率分别为68.75%、43.75%,明显高于对照组的37.50%、15.63%,差异有统计学意义(P<0.05)。实验组与对照组的消化道反应(56.25%vs 31.25%)、放射性食管炎(31.25%vs 21.88%)、进食梗阻(12.50%vs 9.38%)发生率相比较,差异无统计学意义(P>0.05)。结论:低剂量多西他赛周疗同步放疗治疗局部晚期食管癌疗效优于单纯放疗,能够缓解病情,控制肿瘤进展,改善症状,而且应用安全有效,值得临床推广。Objective:To investigate the short-term efficacy and risk of radiotherapy alone combined with low-dose docetaxel in the treatment of locally advanced esophageal cancer.Methods:Sixty-four patients with esophageal cancer who were treated with non-surgical therapy from January 2015 to August 2018 were randomly divided into two groups:The experimental group(32 patients with low-dose docetaxel weekly concurrent radiotherapy) and the control group(32 patients with radiotherapy alone).Short-term efficacy and adverse reactions of the two groups were compared.Results:The effective rate of treatment in the experimental group was 81.25%,and that in the control group was 56.25%,which was significantly higher in the experimental group than in the control group(P<0.05).The incidence of myelosuppression(leukocytosis and thrombocytopenia) in the experimental group was 68.75% and 43.75%,respectively,significantly higher than that in the control group(37.50%,15.63%),with statistically significant differences(P<0.05).The incidence of gastrointestinal reaction(56.25% vs 31.25%),radioactive esophagitis(31.25% vs 21.88%),and eating obstruction(12.50% vs 9.38%) in the experimental group and the control group were not statistically significant(P>0.05).Conclusion:Low-dose docetaxel weekly synchronous radiotherapy is better than radiotherapy alone in the treatment of locally advanced esophageal cancer,which can alleviate the disease,control tumor progression and improve symptoms,and is safe and effective,worthy of clinical promotion.

关 键 词：食管癌 放射治疗 多西他赛 

分 类 号：R735.1[医药卫生—肿瘤]