卵巢浆液性癌中COX-2表达与微血管密度的相关性  

The correlation between expression of COX-2 and microvessel density in ovary serous carcinomas

作　　者：高晓 吴宏培 刘娟妮 刘利英 杨学超 GAO Xiao;WU Hongpei;LIU Juanni;LIU Liying;YANG Xuechao(Department of Pathology,No.215 Hospital of Shaanxi Nuclear Industry,Shaanxi Xianyang 712000,China;Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Shaanxi Xianyang 712000,China;Department of Oncology,No.215 Hospital of Shaanxi Nuclear Industry,Shaanxi Xianyang 712000,China;Department of Gynecology,No.215 Hospital of Shaanxi Nuclear Industry,Shaanxi Xianyang 712000,China)

机构地区：[1]陕西省核工业二一五医院病理科,陕西咸阳712000 [2]陕西中医药大学第一附属医院病理科,陕西咸阳712000 [3]陕西省核工业二一五医院肿瘤科,陕西咸阳712000 [4]陕西省核工业二一五医院妇科,陕西咸阳712000

出　　处：《现代肿瘤医学》2021年第5期844-847,共4页Journal of Modern Oncology

摘　　要：目的:探讨卵巢浆液性癌组织中环氧化酶2(COX-2)的表达与癌组织中微血管密度(microvessel density,MVD)的相关性。方法:应用免疫组织化学染色SP法检测94例卵巢浆液性癌组织中COX-2和CD34的表达,分析癌组织中COX-2的表达与癌组织中MVD的相关性。结果:卵巢浆液性癌组织中COX-2阳性表达56例,阴性表达38例。卵巢浆液性癌94例MVD的中位数为34.33,以34.33为分界线,将其分为两组,高MVD组(44例)和低MVD组(50例)。高MVD组,中位生存时间为16个月,3年生存率为54.55%,5年生存率为27.27%,低MVD组中位生存时间为38个月,3年生存率为78.00%,5年生存率为62.00%。两组间比较,预后差异有统计学意义(P<0.05);COX-2的表达与MVD值呈正相关性(P<0.05)。结论:卵巢浆液性癌中COX-2的表达与新生血管相关,可促进肿瘤的发生、发展。Objective:To explore the relationship between COX-2 expression and microvessel density(MVD)of ovary serous carcinomas.Methods:The expression of COX-2 and CD34 in 94 cases of ovarian serous carcinoma was detected by SP immunohistochemical staining,and the correlation between COX-2 expression and MVD was analyzed.Results:There were 56 cases of COX-2 positive and 38 cases of COX-2 negative expression in ovarian serous carcinoma.The median value of MVD in 94 patients with ovarian serous carcinoma was 34.33,which was divided into two groups,high MVD group(44 cases) and low MVD group(50 cases).In high MVD group,the median survival time was 16 months,3-year survival rate was 54.55%,5-year survival rate was 27.27%,and in low MVD group,the median survival time was 38 months,3-year survival rate was 78.00%,5-year survival rate was 62.00%.There was a significant difference in prognosis between the two groups(P<0.05).The expression of COX-2 was positively correlated with MVD(P<0.05).Conclusion:COX-2 expression in ovarian serous carcinoma is related to neovascularization,which can promote the occurrence and development of tumor.

关 键 词：卵巢浆液性癌 COX-2 微血管密度 

分 类 号：R737.31[医药卫生—肿瘤]