Notch信号通路与肿瘤细胞凋亡的研究进展  

Advance of Notch signaling pathway regulating cell apoptosis in malignant tumor

作　　者：吴振 胡彦建 尹琦 胡彦华[1] WU Zhen;HU Yanjian;YIN Qi;HU Yanhua(Department of General Surgery,the Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150086,China;Department of Gastroenterology and Hepatology,Harbin First Hospital of Affiliated to Harbin Institute of Technology,Heilongjiang Harbin 150010,China)

机构地区：[1]哈尔滨医科大学附属第二医院普通外科,黑龙江哈尔滨150086 [2]哈尔滨工业大学附属哈尔滨市第一医院消化内科,黑龙江哈尔滨150010

出　　处：《现代肿瘤医学》2021年第5期901-906,共6页Journal of Modern Oncology

基　　金：黑龙江省卫生计生委科研课题(编号:2018-347);黑龙江省博士后科研启动基金(编号:LBH-Q14110)。

摘　　要：Notch信号通路是一种生物进化中高度保守的信号转导通路,在多种细胞的增殖、分化和凋亡中起到关键作用。目前Notch信号通路的配体和受体,以及信号转导途径已经基本研究阐明,有关Notch信号通路与肿瘤细胞凋亡的研究也取得了较大的进展。本文综述了Notch信号通路对血液恶性肿瘤和实体肿瘤细胞凋亡的影响及机制的最新研究结果,重点回顾了Notch信号通路对不同种类肿瘤细胞凋亡的高背景相关性,以及Notch信号通路与其它细胞信号通路之间的串扰,及对肿瘤细胞凋亡的影响。Notch signaling pathway is a highly evolutionarily conserved signaling pathway,which plays a key role in a wide array of cellular processes including proliferation,differentiation,and apoptosis.Recently,we have known the receptor,ligand,and transduction process of Notch signaling pathway,and also made significant progress in research of Notch signaling pathway regulating apoptosis in malignant tumor.This overview is on currently novel advances about the role and mechanism of Notch signaling pathway in hematological and solid malignancy cell apoptosis.The focus of this article will review the highly context dependent nature of the Notch signaling pathway in various subtype cell,and the effect of cross-talk between Notch signaling pathway and other signaling pathway regulating apoptosis in malignant tumor.

关 键 词：NOTCH信号通路 肿瘤细胞 凋亡 机制 

分 类 号：R730[医药卫生—肿瘤]