三维可视化联合吲哚菁绿荧光影像技术在原发性肝癌诊治中的价值及临床检出率观察  

Value of three-dimensional visualization combined with indocyanine green fluorescence imaging in diagnosis and treatment of primary liver cancer and observation of clinical detection rate

作　　者：沈正超[1] 陈鹏 周琰 Shen Zhengchao;Chen Peng;Zhou Yan(The Yijishan Hospital of Wannan Medical College,Wuhu,AnHui 241001)

机构地区：[1]皖南医学院弋矶山医院,安徽芜湖241001

出　　处：《基层医学论坛》2021年第4期463-465,共3页The Medical Forum

基　　金：皖南医学院自然科学研究类项目(WK2018F21)。

摘　　要：目的探讨三维可视化联合吲哚菁绿荧光影像技术在原发性肝癌诊治中的价值及临床检出率。方法回顾性分析皖南医学院弋矶山医院肝胆外科2017年4月—2019年5月收治的94例原发性肝癌患者的临床资料,抽签法随机分成对照组与观察组各47例。对照组仅实施常规手术评估及切除,观察组术前采用三维可视化技术规划手术方案,术中采用吲哚菁绿荧光影像技术实时判断肿瘤位置、边界及转移病灶完成手术,对2组术中肿瘤探测情况、术后实验室指标、病理信息及随访信息进行分析对比。结果观察组患者术前增强CT发现病灶52个,术中吲哚菁绿分子荧光发现病灶68个,与术前增强CT结果比较,多发现病灶16个,术后病理诊断为肝癌10个,肝硬化结节6个。与对照组比较,观察组手术用时更短,术中失血量更少(P<0.05);观察组与对照组术后并发症发生率分别为6.38%及23.40%,差异显著(P<0.05);观察组12个月后肿瘤复发率4.26%(2/47),显著低于对照组19.15%(9/47);观察组总体无瘤生存率74.47%(35/47),显著高于对照组的29.79%(14/47)(P<0.05)。结论三维可视化联合吲哚菁绿荧光影像技术可提高原发性肝癌的检出率,为患者提供更为精确的术前诊断及手术规划,通过精准导航成功切除病灶,使得术后并发症及肿瘤复发率降低,延长生存时间。Objective To explore the value and clinical detection rate of three-dimensional visualization combined with indocyanine green fluorescence imaging in the diagnosis and treatment of primary liver cancer.Methods The clinical data of 94 patients with primary liver cancer treated in hepatobiliary surgery in our hospital from April 2017~May 2019 were retrospectively analyzed.All patients were randomly divided into two groups:control group and observation group,47 cases each.The control group was only evaluated and resected by routine operation.Three-dimensional visualization technique was used to plan the operation plan before operation,and indocyanine green fluorescence imaging technique was used to determine the tumor location,boundary and metastasis in real time.For Intraoperative tumor detection,postoperative laboratory indicators,pathological information and follow-up information were analyzed.Results In the observation group,52 lesions were found by enhanced CT before operation,Intraoperative fluorescence of indocyanine green showed 68 lesions,Compared with the results CT preoperative enhancement,More than 16 lesions,Postoperative pathological diagnosis of liver cancer 10,Liver cirrhosis nodule 6;Compared with the control group,The operation in the observation group was shorter,(b)Less intraoperative blood loss(P<0.05);The incidence of postoperative complications in observation group and control group was 6.38%and 23.40%,respectively,Comparison between groups was significant(P<0.05);Swelling after 12 months in observation group Tumor recurrence rate was 4.26%(2/47),significantly lower than that of control group 19.15%(9/47),and overall tumor-free survival rate in observation group was 74.47%(35/47),significantly higher than that in control group 29.79%(14/47)(P<0.05).Conclusion 3D visualization combined with indocyanine green fluorescence imaging can improve the detection rate of primary liver cancer,provide more accurate preoperative diagnosis and surgical planning for patients,and successfully remove the lesio

关 键 词：原发性肝癌 三维可视化 吲哚菁绿荧光影像技术 临床价值 检出率 

分 类 号：R73[医药卫生—肿瘤]