合肥地区食管鳞状细胞癌患者HPV感染调查及HR-HPV感染与预后的关系  

Investigation of HPV infection in esophageal squamous cell carcinoma patients in Hefei area and the relationship between HR-HPV infection and prognosis

作　　者：吴莉莉 田静 王红群[1] 王庆梅[1] 李学敏 WU Lili;TIAN Jing;WANG Hongqun;WANG Qingmei;LI Xuemin(The Third People's Hospital of Hefei,Anhui Hefei 230032,China)

机构地区：[1]合肥市第三人民医院,安徽合肥230032

出　　处：《现代肿瘤医学》2021年第6期964-968,共5页Journal of Modern Oncology

基　　金：合肥市科技攻关计划(编号:合科[2017]3号)。

摘　　要：目的:对合肥地区食管鳞状细胞癌患者人乳头瘤病毒(HPV)感染情况进行调查分析,并探讨高危型HPV(HR-HPV)感染与患者预后的关系。方法:选取2013年06月至2019年02月本院收治的384例合肥地区食管鳞状细胞癌(包括食管鳞状上皮高级别上皮内瘤变伴癌变)患者,均行HPV检测。统计分析纳入研究患者HPV感染情况,另手术/放化疗治疗后随访1年,根据预后情况将患者分为预后良好组及预后不良组,并采用多因素Logistic回顾性分析法分析HR-HPV感染与食管鳞状细胞癌患者预后的关系。结果:384例食管鳞状细胞癌患者中HPV感染率为36.72%,其中低危HPV感染占比为9.93%,HR-HPV占比为90.07%,基因型由高到低分别为16型、18型、52型、33型、6型、51型、58型、11型;随访1年,384例食管鳞状细胞癌患者预后不良率为57.03%(219/384),预后不良组HR-HPV感染率明显高于预后良好组(P<0.05);经Logistic回顾分析显示,癌症低分化或未分化或中分化、临床分期Ⅳ期或Ⅲ期、淋巴结转移、饮酒史、HR-HPV感染均是食管鳞状细胞癌患者预后不良的危险因素(OR=3.916、2.581、4.080、3.238、4.821、2.986、3.062,P<0.05)。结论:合肥地区食管鳞状细胞癌患者HPV感染率较高,并以HPV16、18等高危型为主,且HR-HPV感染可增加食管鳞状细胞癌患者预后不良发生风险。Objective:To investigate the infection of human papillomavirus(HPV)in patients with esophageal squamous cell carcinoma in Hefei area,and to explore the relationship between high risk HPV(HR-HPV)infection and prognosis.Methods:384 patients with esophageal squamous cell carcinoma(including esophageal squamous intraepithelial neoplasia with canceration)in Hefei admitted in our hospital from June 2013 to February 2019 were selected,who were detected for HPV.HPV infection in the patients included in the study were analyzed statistically,and the patients were divided into good prognosis group and poor prognosis group according to the prognosis followed up for 1 year after operation/radiotherapy and chemotherapy,then the relationship between HR-HPV infection and the prognosis of esophageal squamous cell carcinoma patients was also analyzed by multivariate Logistic analysis.Results:In 384 cases of esophageal squamous cell carcinoma,the infection rate of HPV was 36.72%,of which the low-risk HPV infection accounted for 9.93%,of which the HR-HPV accounted for 90.07%,and the genotypes from high to low were 16,18,52,33,6,51,58 and 11 respectively.During the follow-up of 1 year,the poor prognosis rate of 384 esophageal squamous cell carcinoma patients was 57.03%(219/384),and the HR-HPV infection rate in the poor prognosis group was significantly higher than that in the good prognosis group(P<0.05).Logistic analysis showed that the poorly or undifferentiated or moderately differentiated cancer,clinical stageⅣorⅢ,lymph node metastasis,drinking history and HR-HPV infection were the risk factors for the poor prognosis of esophageal squamous cell carcinoma(OR=3.916,2.581,4.080,3.238,4.821,2.986,3.062,P<0.05).Conclusion:There are high HPV infection rate in patients with esophageal squamous cell carcinoma in Hefei area,and HPV16 and HPV18 and other high-risk types are the main types,and HR-HPV infection can increase the risk of poor prognosis in patients with esophageal cancer.

关 键 词：食管鳞状细胞癌 人乳头瘤病毒 高危型 预后 

分 类 号：R735.1[医药卫生—肿瘤]