客家人群血管性认知功能障碍相关危险因素分析  

Analysis of risk factors related to vascular cognitive dysfunction in Hakka population

作　　者：邹友权[1] 罗彬文 罗海龙[1] 许伟[1] 周坤元[1] Zou Youquan;Luo Binwen;Luo Hailong;Xu Wei;Zhou Kunyuan(Department of Neurology,Meizhou People's Hospital,Meizhou 514031)

机构地区：[1]梅州市人民医院,广东梅州441400

出　　处：《辽宁医学杂志》2021年第1期51-54,共4页Medical Journal of Liaoning

摘　　要：目的分析客家人群血管性认知功能障碍(VCI)相关危险因素。方法回顾性分析215例VCI患者病例资料,以年龄段分3组,<70岁为A组,55例;≥70岁且<80岁为B组,80例;≥80岁为C组,80例;另选同期非VCI 50例患者为对照组;3组分别与对照组及组间比较,性别、血压、血脂、血糖或糖化血红蛋白、超敏C反应蛋白、同型半胱氨酸、烟酒嗜好、卒中史、病灶部位等相关临床资料,应用单因素和多因素Logistic回归分析显示影响其发生的危险因素。结果因素分析显示:年龄、糖化血红蛋白、高血压、关键部位病灶、超敏C反应蛋白、同型半胱氨酸、脑卒中史与血管性认知功能障碍显著相关。进一步Logistic回归分析显示:糖化血红蛋白、高血压、血脂、优势半球卒中史、关键部位病灶、超敏C反应蛋白、同型半胱氨酸是其独立危险因素。结论随着年龄增长,应重点注意高血压、糖尿病、优势半球卒中史、关键部位病灶及脑白质疏松情况,对患者做出正确的评估,减少VCI的发生。Objective Analysis of risk factors associated with vascular cognitive impairment(VCI)in Hakka population.Methods The data of 215 patients with VCI were retrospectively analyzed.The age group was divided into 3 groups,<70 years old for group A,55 cases;≥70 years old and<80 years old for group B,80 cases;≥80 years old for group C,80 cases;Another 50 patients with non-VCI in the same period were selected as the control group.3 groups were compared with the control group and the group,blood pressure,blood lipids,blood sugar or glycation Clinical data of hemoglobin,high-sensitivity C-reactive protein,homocysteine,tobacco and alcohol hobby,stroke history,and lesion site,using single factor and multivariate logistic regression analysis to show the risk factors affecting it.Results Factor analysis showed that age,glycosylated hemoglobin,hypertension,key site lesions,high-sensitivity C-reactive protein,homocysteine,and stroke history were significantly associated with vascular cognitive dysfunction.Further logistic regression analysis showed that glycosylated hemoglobin,hypertension,blood lipids,history of dominant hemisphere stroke,key site lesions,high-sensitivity C-reactive protein,and homocysteine were independent risk factors.Conclusion With age,attention should be paid to hypertension,diabetes,history of dominant hemisphere stroke,key site lesions and leukoaraiosis,and correct assessment of patients to reduce the incidence of VCI.

关 键 词：血管性认知功能障碍 年龄 危险因素 

分 类 号：R749.13[医药卫生—神经病学与精神病学]