中性粒细胞及血小板与淋巴细胞的比值在食管癌诊断及预后中的研究  

A study on the ratios of neutrophils and platelets to lymphocytes in the diagnosis and prognosis of esophageal cancer

作　　者：刘艳清 吴爱华 莫翼军[1] 王姗姗 罗守军[1] LIU Yan-qing;WU Ai-hua;MUO Yi-jun;WANG Shan-shan;LUO Shou-jun(Clinical Laboratory,the First Hospital of Ningbo,Ningbo,Zhejiang 315000,China)

机构地区：[1]宁波市第一医院检验科,浙江宁波315000

出　　处：《中国卫生检验杂志》2021年第2期179-182,共4页Chinese Journal of Health Laboratory Technology

基　　金：宁波市科技惠民项目(2017C50036)。

摘　　要：目的评估食管癌患者中性粒细胞与淋巴细胞比率(NLR)、血小板与淋巴细胞比率(PLR)及其他临床参数与食管癌(EC)的关系,并进一步探讨这些炎症标志物作为EC诊断及预后指标的可能性。方法回顾性分析2015年1月-2019年1月本院106例食管癌患者、40例食管异型增生(ED)患者和102例食管良性肿瘤(BET)患者。根据组织学类型、肿瘤分期和转移将106例EC患者分组。比较全血细胞计数、CEA、CA19-9、CA72-4、CYF21和NSE,计算104例EC患者的预后营养指数(PNI)。同时选取200例健康者作为对照。结果 EC患者的NLR和PLR水平显著高于ED、BET和NC(P <0.001)。ROC分析显示NLR和PLR区分EC与ED和BET的最佳临界值分别为3.07和160.33。升高的NLR和PLR与较高的肿瘤分期和转移相关(P <0.05)。Pearson相关分析表明,NLR和PLR均与PNI呈负相关(r=-0.336,r=-0.443,P <0.001)。结论 NLR和PLR可以区分EC患者与ED和BET患者。NLR和PLR可以用作EC患者的营养状况评估、疾病进展及预后的潜在标志物。Objective The purpose of the study is to evaluate the levels of the neutrophil to lymphocyte ratio(NLR),the platelet to lymphocyte ratio(PLR) and other clinical parameters in patients with esophageal cancer(EC) and further to explore the potential diagnosis and prognosis for these markers in EC. Methods 106 patients with ECC,40 patients with esophageal dysplasia(ED),102 patients with benign esophageal tumor(BET),and 200 normal controls(NC) were entered in the study.104 patients with EC were grouped together according to histological type,tumor stages and metastasis status. Besides,the prognostic nutritional index(PNI) was determined for EC patients. At the same time,200 healthy individuals were selected as controls. Results The results showed that EC patients had higher levels of NLR and PLR than ED,BET and NC(P <0. 001). ROC analysis showed that the optimal cut-off values of NLR and PLR for EC and ED and BET were 3. 07 and 160. 33,respectively. Elevated NLR and PLR were associated with higher tumor stage and metastasis(P < 0. 05). Pearson correlation analysis showed that NLR and PLR were negatively correlated with PNI(r =-0. 336,r =-0. 443,P < 0. 001).Conclusion NLR and PLR might discriminate between EC patients and patients with ED and BET. NLR and PLR might be used as a potential prognostic marker in EC patients in their relationships with nutritional status,disease progression and prognosis.

关 键 词：中性粒细胞与淋巴细胞比率 血小板与淋巴细胞比率 食管癌 预后营养指数 

分 类 号：R735.1[医药卫生—肿瘤]