无症状头颅磁共振脑缺血灶相关危险因素的病例对照研究  

A case-control study on risk factors related to the non-symptomatic focal cerebral ischemia detected by MRI

作　　者：张明华[1] 张增强[2] 崔芳[2] 彭志晴[3] 王雪[4] ZHANG Ming-hua;ZHANG Zeng-qiang;CUI Fang;PENG Zhi-qing;WANG Xue(Department of Cardiology,the Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第二医学中心心内科,北京100853 [2]解放军总医院海南医院神经内科,海南三亚572013 [3]解放军总医院海南医院保健科,海南三亚572013 [4]解放军总医院海南医院放射科,海南三亚572013

出　　处：《中国实用内科杂志》2021年第1期60-63,共4页Chinese Journal of Practical Internal Medicine

基　　金：海南省自然科学基金(2018CXTD348)。

摘　　要：目的研究无症状头颅磁共振脑缺血灶相关的危险因素。方法选取2015—2018年解放军总医院海南医院保健科常规体检头颅磁共振检查检出的无症状头颅磁共振缺血灶者67例为病例组,另选配常规体检同性别、年龄相近(±2岁)、头颅磁共振检查未见异常者67例作为对照组。对照比较分析2组人员的临床特征、颈动脉超声检查结果和血糖、血脂、同型半胱氨酸、胱抑素C等血液生化指标。结果与对照组比较,病例组颈动脉内-中膜增厚较多(P<0.05),收缩压(P<0.05)、舒张压(P<0.01)水平显著升高。经logistic回归分析显示,颈动脉内中膜增厚(P<0.01)和舒张压高(P<0.05)是无症状头颅磁共振脑缺血灶的独立相关危险因素。结论颈动脉内-中膜增厚和血压高(尤其是舒张压高)是无症状头颅磁共振脑缺血灶的相关风险因素。Objective To investigate the risk factors related to the non-symptomatic focal cerebral ischemia detected by magnetic resonance imaging(MRI).Methods A total of 67 non-symptomatic subjects with focal cerebral ischemia detected by cranial MRI on routine physical check-up between 2015 and 2018 were included as the case group.Matched by sex and age(±2 years),another 67 non-symptomatic subjects without abnormal findings detected by cranial MRI in the same period of time on routine physical check-up were selected as the control group.Clinical characteristics,results of Doppler carotid echography and blood biochemical parameters were compared and analyzed statistically between the two groups.Results Compared with the control group,there was more high carotid intima-media thickness(IMT)in the case group(P<0.05).Systolic blood pressure(P<0.05)and diastolic blood pressure(P<0.01)are higher in the case group than in the control group.The logistic analysis showed that high IMT(P<0.01)and high diastolic blood pressure(P<0.05)were independent telated risk factors for non-symptomatic focal cerebral ischemia detected by MRI.Conclusion High IMT and high blood pressure,especially the high diastolic blood pressure,are the related risk factors for non-symptomatic focal cerebral ischemia detected by MRI.

关 键 词：无症状 脑缺血灶 磁共振成像 颈动脉内-中膜增厚 危险因素 

分 类 号：R743[医药卫生—神经病学与精神病学]