丙酮酸钠药理学作用的研究现状  

Research status on the pharmacological effects of sodium pyruvate

作　　者：李敏[1,3] 马凌云[1] 陈超阳[1,3] 周颖 杨艳玲[2] 崔一民[1,3] LI Min;MA Ling-yun;CHEN Chao-yang;ZHOU Ying;YANG Yan-ling;CUI Yi-min(La Department of Pharmacy,Peking University First Hospital,Beijing 100034,China;b.Department of Pediatrics,Peking University First Hospital,Beijing 100034,China;Department of Pharmacy Administration and Clinical Pharmacy,School of Pharmaceutical Science,Peking University,Beijing 100191,China)

机构地区：[1]北京大学第一医院药学部,北京100034 [2]北京大学第一医院儿科,北京100034 [3]北京大学医学部药学院药事管理与临床药学系,北京100191

出　　处：《中国临床药理学杂志》2021年第3期341-344,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家科技重大专项课题资助项目(2018ZX09721003-008,2017ZX09304029-006-001)。

摘　　要：丙酮酸钠作为一种常见的丙酮酸盐,在科学研究和日常生活中应用广泛。丙酮酸钠可用于基础研究和临床测定,也是常用的医药原料、食品添加剂和减肥膳食补充剂等。丙酮酸钠具有抗氧化、抗炎、预防代谢性酸中毒、改善能量代谢障碍等作用,且其抗休克、改善缺血/再灌注损伤等具有治疗优势。本文就丙酮酸钠的药理学作用进行整理综述,以期进一步探究丙酮酸钠的临床应用。Sodium pyruvate as a common form of pyruvate is widely used in scientific research and daily life. Sodium pyruvate can be applied for basic research and clinical determination, and it is also a commonly used pharmaceutical raw material, food additive and dietary supplement for weight loss. Sodium pyruvate has some effects on antioxidant, anti-inflammatory, prevention of metabolic acidosis and improvement of energy metabolism disorders, and it owns some therapeutic advantages in resisting shock and improving ischemia/reperfusion injury. The review focuses on the recent developments of pharmacological effects of sodium pyruvate, in order to further explore the clinical application of sodium pyruvate.

关 键 词：丙酮酸钠 抗氧化 能量代谢障碍 酸中毒 罕见病 

分 类 号：R97[医药卫生—药品]