外用2%盐酸卡替洛尔和0.5%马来酸噻吗洛尔滴眼液治疗浅表性婴儿血管瘤临床观察  

Topical 2%Carteolol Hydrochloride Eye Drops and 0.5%Timolol Maleate Eye Drops in the Treatment of Low or Medium Risk Infantile Hemangioma

作　　者：刘建中[1] 邓霞 谭卫群[3] 李萍[1,2] 李建红 罗珍[1] 朱思虹[1] 石航 LIU Jianzhong;DENG Xia;TAN Weiqun;LI Ping;LI Jianhong;LUO Zhen;ZHU Sihong;SHI Hang(Department of Dermatology,Shenzhen Children's Hospital,Shenzhen 518038,China;Zhuhai Campus of Zunyi Medical College,Zhuhai 519041,China;Department of Cardiology,Shenzhen Children's Hospital,Shenzhen 518038,China)

机构地区：[1]广东省深圳市儿童医院皮肤科,广东深圳518038 [2]深圳遵义医学院珠海校区,广东珠海519041 [3]广东省深圳市儿童医院心血管内科,广东深圳518038

出　　处：《中国皮肤性病学杂志》2021年第3期277-282,共6页The Chinese Journal of Dermatovenereology

基　　金：深圳市卫生和计划生育委员会(SZFZ2017065)。

摘　　要：目的观察外用2%盐酸卡替洛尔滴眼液和0.5%马来酸噻吗洛尔滴眼液治疗中低风险、浅表性、增殖期婴儿血管瘤的疗效及安全性。方法采用随机开放平行对照试验将240例患者分为卡替洛尔组和噻吗洛尔组,最后分析201例患者的临床资料,分别对治疗后1个月、3个月和6个月时的疗效及不良反应进行组内和组间比较。结果卡替洛尔组(105例)和噻吗洛尔组(96例)治疗后1个月、3个月、6个月时的有效率分别为18.10%和22.92%、63.81%和83.33%、82.86%和91.67%,表明随着用药时间的延长,有效率逐渐增高,疗程和疗效呈正相关(P均=0.00)。两组在用药后1个月和6个月时的有效率差异无统计学意义(P均>0.05),表明两种药物的起效时间和远期疗效无明显差别。总不良反应发生率:卡替洛尔组为6.67%(7/105),噻吗洛尔组为4.17%(4/96),差异未见统计学意义(P>0.05)。湿疹和溃疡为常见局部不良反应,其中卡替洛尔组7例(湿疹5例、溃疡2例)、噻吗洛尔组4例(湿疹3例、溃疡1例)。仅噻吗洛尔组的1例患者出现一过性不完全性房室传导阻滞,两组均未出现其他系统不良反应。结论2%盐酸卡替洛尔滴眼液和0.5%马来酸噻吗洛尔滴眼液局部治疗中低风险、浅表性、增殖期婴儿血管瘤疗效肯定,随用药时间的延长,疗效增加。湿疹为局部常见不良反应,长期使用极少发生系统不良反应。两药均可作为婴儿血管瘤的治疗选择。Objective To compare the efficacy and safety of 2%carteolol eye drops and 0.5%timolol eye drops in the treatment of low or medium risk,proliferative superficial infantile hemangioma.Methods A randomized,open parallel controlled trial was conducted in 240 cases of infantile hemangioma which were divided into carteolol and timolol group.The efficacy and adverse reactions at 1 month,3 months and 6 months after treatment were analyzed.Results A total of 201 cases were analyzed.The effective rates of carteolol group(105 cases)and timolol group(96 cases)at 1 month,3 months and 6 months were 18.10%/22.92%,63.81%/83.33%and 82.86%/91.67%,respectively.The course of treatment was positively correlated with the curative effect(P=0.00).There was no statistical difference in the effective rate between the two groups at 1 month and 6 months(P>0.05).The incidence of total adverse reactions was 6.67%(7/105)in the carteolol group and 4.17%(4/96)in the timolol group,with no statistical difference(P>0.05).Eczema and ulcer were common local adverse reactions,of which 7 cases were in the carteolol group(5 cases eczema,2 cases ulcer)and 4 cases were in the timolol group(3 cases eczema,1 case ulcer).Only 1 patient in timolol group presented transient incomplete atrioventricular block,and no other systemic adverse reactions occurred in both groups.Conclusion Both 2%carteolol eye drops and 0.5%timolol eye drops are effective in topical therapy of infantile hemangioma with low or medium risk,superficial and proliferative phase.Eczema is a common adverse reaction.Adverse systemic reactions are rare.

关 键 词：卡替洛尔 噻吗洛尔 外用 中低风险 浅表性 增殖期 婴儿血管瘤 

分 类 号：R739.5[医药卫生—肿瘤]