葛根芩连汤加味联合低FODMAP饮食对溃疡性结肠炎患者的疗效影响  

Influence of Gegen Qinlian Decoction Combined with Low FODMAP Diet on Patients with Ulcerative Colitis

作　　者：陈燕 章小艳 黄益倩 童晓清[2] 郑培奋[2] 汪涛[3] 束龙[2] Chen Yan;Zhang Xiaoyan;Huang Yiqian(Department of Nutrition and Gastroenterology,Zhejiang Hospital,Zhejiang 310013,China)

机构地区：[1]浙江医院消化内科,杭州310013 [2]浙江医院临床营养科,杭州310013 [3]浙江医院中医内科,杭州310013

出　　处：《医学研究杂志》2021年第2期69-73,共5页Journal of Medical Research

基　　金：浙江省自然科学基金资助项目(LY17H030008);浙江省中医药科研基金资助项目(2020ZB009);浙江省卫生厅一般项目(2017KY190)。

摘　　要：目的探讨葛根芩连汤联合低FODMAP饮食对轻中度溃疡性结肠炎(UC)患者的疗效影响。方法纳入2018年10月~2020年7月于浙江医院消化内科就诊的轻中度活动性UC患者97例为研究对象,按照数字表法随机分为治疗组(A组30例和B组35例)和对照组(C组32例)。对照组予美沙拉嗪+普通饮食,治疗组包括饮食干预及联合干预,分别给予低FODMAP饮食+美沙拉嗪、辨证使用葛根芩连汤+低FODMAP饮食+美沙拉嗪。3组患者均临床治疗6周,随访6周。比较3组患者治疗前后的炎性细胞因子指标、营养状况指标及临床治疗效果;观察每周UC患者症状变化。结果临床治疗后,3组患者的Mayo评分、炎性细胞因子水平较治疗前均明显降低,差异有统计学意义(P<0.05)。A、B组患者在Mayo评分、炎性细胞因子水平及临床治疗效果方面显著优于C组,差异有统计学意义(P<0.05);而治疗后B组患者C反应蛋白水平与C组比较,差异无统计学意义。治疗前后,3组患者营养相关指标均未发生明显变化,差异无统计学意义(P>0.05)。结论在常规治疗的基础上,葛根芩连汤联合低FODMAP饮食能有效改善轻中度活动性UC患者的临床症状。Objective To explore the effect of Gegen Qinlian Decoction combined with low FODMAP diet on patients with mild to moderate ulcerative colitis(UC).Methods A total of 97 patients with mild to moderately active UC who were treated in the Department of Gastroenterology of Zhejiang Hospital from October 2018 to July 2020 were selected as the research subjects.They were divided into treatment groups(30 cases in group A and 35 cases in group B)and control group(32 cases in group C).The control group was given ordinary diet+mesalazine,and the treatment groups included dietary intervention and joint intervention.They were given low-FODMAP diet+mesalazine,and dialectical use of Gegen Qinlian Decoction+low-FODMAP diet+mesalazine.Patients in the three groups were treated clinically for 6 weeks and followed up for 6 weeks.The inflammatory factor indexes,nutritional status indexes and clinical treatment effects of the three groups of patients were compared before and after treatment.The weekly changes in symptoms of UC patients were observed.Results After clinical treatment,the Mayo score and inflammatory factor levels of the 3 groups were significantly lower than before treatment,and the difference was statistically significant(P<0.05).The Mayo score,inflammatory factor levels and clinical treatment effects of patients in groups A and B significantly better than group C,and the difference was statistically significant(P<0.05).After treatment,the level of C-reactive protein in group B was not significantly lower than that in group C.Before and after treatment,there was no significant change in nutrition-related indicators of the 3 groups,and the difference was not statistically significant(P>0.05).Conclusion On the basis of conventional treatment,gegen qinlian Decoction combined with low FODMAP diet can effectively improve the clinical symptoms of patients with mild to moderate active UC.

关 键 词：低FODMAP饮食 葛根芩连汤 美沙拉嗪 溃疡性结肠炎 

分 类 号：R574.6[医药卫生—消化系统]