芍药甘草汤加减对急性胃溃疡患者血清炎症因子、胃黏膜表皮生长因子及受体表达的影响  

Effect of Modified Shaoyao Gancao Decoction on the Expression of Serum Inflammatory Factors,Gastric Mucosal Epidermal Growth Factor and Receptor in Patients with Acute Gastric Ulcer

作　　者：袁奕清 胡小军 YUAN Yi-qing;HU Xiao-jun(Department of Traditional Chinese Medicine,Wuhan Puren Hospital,Wuhan Hubei 430081)

机构地区：[1]武汉市普仁医院中医科,湖北武汉430081

出　　处：《世界中西医结合杂志》2021年第1期92-95,99,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：武汉市卫计委面上项目(S201802130014)。

摘　　要：目的探讨芍药甘草汤加减治疗急性胃溃疡的疗效及对患者血清炎症因子、胃黏膜表皮生长因子(Epidermal growth factor,EGF)及表皮生长因子受体(Epithelial growth factor receptor,EGFR)表达的影响。方法选取2017年1月—2019年1月期间于武汉市普仁医院中医科收治的84例急性胃溃疡患者,采用随机数字表法分为两组,每组各42例,对照组应用西药进行常规治疗,治疗组在对照组基础上加用芍药甘草汤加减。比较两组患者治疗前后的中医症状评分,血清炎症因子,胃黏膜EGF、EGFR水平变化,临床疗效及不良反应情况。结果两组患者治疗后胃脘胀满、脘痛连胁、胸闷、反酸、嗳气证候积分均较治疗前明显降低(P<0.05),且治疗组患者胃脘胀满、脘痛连胁、胸闷、反酸、嗳气证候积分均显著低于对照组(P<0.05)。两组患者治疗后血清炎症因子CRP、TNF-α、IL-6水平均较治疗前明显降低(P<0.05),且治疗组治疗后CRP、TNF-α、IL-6水平均显著低于对照组(P<0.05)。两组患者治疗后胃黏膜EGF、EGFR表达水平均较治疗前明显升高(P<0.05),且治疗组治疗后胃黏膜EGF、EGFR表达水平均显著高于对照组(P<0.05)。治疗后治疗组总有效率为90.48%(38/42)显著高于对照组69.05%(29/42)(P<0.05)。治疗期间两组患者均未见明显不良反应。结论芍药甘草汤加减治疗急性胃溃疡能有效缓解临床症状,减轻炎症反应,提高胃黏膜EGF、EGFR表达水平,发挥胃黏膜保护作用,从而提高治疗效果。Objective To investigate the curative effect of Shaoyao Gancao Decoction in the treatment of acute gastric ulcer and its effect on the expression of serum inflammatory factors,epidermal growth factor(EGF)and epidermal growth factor receptor(EGFR)in patients with gastric mucosa.Methods A total of 84 patients with acute gastric ulcer who were admitted to the Department of Traditional Chinese Medicine of Wuhan Puren Hospital from January 2017 to January 2019 were divided into two groups using a random number table,each with 42 cases.The control group was treated with western medicine.For conventional treatment,the treatment group added Shaoyao Gancao Decoction on the basis of the control group.The TCM symptom scores,serum inflammatory factors,gastric mucosal EGF and EGFR levels,clinical efficacy and adverse reactions were compared between the two groups before and after treatment.Results After treatment,the scores of gastric fullness,epigastric pain,chest tightness,acid reflux,and belching syndrome were significantly lower in the two groups than before treatment(P<0.05),and patients in the treatment group had gastric fullness and epigastric pain.The scores of,chest tightness,acid reflux,and belching were significantly lower than those of the control group(P<0.05).The levels of serum inflammatory factors CRP,TNF-α,and IL-6 after treatment in the two groups were significantly lower than before treatment(P<0.05),and the levels of CRP,TNF-α,and IL-6 in the treatment group after treatment were significantly lower than those of the control Group(P<0.05).The expression levels of EGF and EGFR in the gastric mucosa after treatment in the two groups were significantly higher than those before treatment(P<0.05),and the increase in the treatment group was more obvious.The expression levels of EGF and EGFR in the gastric mucosa after treatment in the treatment group were significantly higher than those before treatment.Control group(P<0.05).After treatment,the total effective rate of the treatment group was 90.48%(38/42)signif

关 键 词：芍药甘草汤 急性胃溃疡 炎症因子 胃黏膜表皮生长因子 中医证候 

分 类 号：R573.1[医药卫生—消化系统]