固肠止泻丸联合康复新液灌肠治疗对溃疡性结肠炎患者肠道菌群及炎症因子的影响  

Effect of Guchang Zhixie Pills Combined with Kangfuxin Enema on Intestinal Flora and Inflammatory Factors in Patients with Ulcerative Colitis

作　　者：王金周[1] 王萍[2] 侯亭开 张运希[2] WANG Jin-zhou;WANG Ping;HOU Ting-kai;ZHANG Yun-xi(Department of Medical Affairs,Anyang Hospital of Traditional Chinese Medicine,Anyang Henan 455000;Department of Hepatobiliary,Spleen and Stomach,Anyang Hospital of Traditional Chinese Medicine,Anyang Henan 455000)

机构地区：[1]安阳市中医院医务科,河南安阳455000 [2]安阳市中医院肝胆脾胃科,河南安阳455000

出　　处：《世界中西医结合杂志》2020年第12期2289-2293,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河南省中医药科学研究专项课题(2016ZY03026)。

摘　　要：目的观察固肠止泻丸联合康复新液灌肠治疗对溃疡性结肠炎患者肠道菌群和炎症因子的影响。方法将84例溃疡性结肠炎患者分为对照组(42例)和观察组(42例),对照组口服柳氮磺吡啶肠溶片治疗,观察组在对照组治疗基础上口服固肠止泻丸联合康复新液灌肠治疗。治疗后观察两组临床疗效,通过中医证候评分表(QOL)和生活质量评分表对治疗前后中医症状和生活质量进行评估,同时检测患者肠道菌群指标和营养指标,并通过酶联免疫吸附法检测患者炎症因子水平[白介素-6(IL-6)、白介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)]以及血清白蛋白(ALB)水平,最后记录治疗期间两组患者不良反应发生情况。结果观察组治疗后总有效率明显高于对照组(P<0.05);治疗后观察组粪便球杆比低于1/10的治愈患者明显高于对照组,而观察组无明显改善的患者(粪便球杆比>1/6)明显低于对照组(P<0.05);两组治疗后厌氧杆菌和拟杆菌数量明显增加(P<0.05),而大肠杆菌和铜绿假单胞菌显著减少(P<0.05),观察组肠道菌群指标改善程度明显优于对照组(P<0.05);两组治疗后炎症因子(IL-6,IL-17,TNF-α)水平较本组治疗前明显降低(P<0.05),且观察组显著低于对照组(P<0.05);两组治疗后QOL评分高于本组治疗前,中医证侯评分低于本组治疗前(P<0.05);观察组治疗后中医证侯评分明显低于对照组,而QOL评分显著高于对照组(P<0.05),差异具有统计学意义;两组治疗后体质量指数(BMI)、理想体质量百分比(IBW%)以及ALB水平较本组治疗前明显增加(P<0.05),且观察组患者营养指标改善情况明显优于对照组(P<0.05)。结论口服固肠止泻丸联合康复新液灌肠治疗溃疡性结肠炎患者疗效佳,能够调节肠道菌群,改炎症因子水平,不良反应少。Objective To observe the effect of Guchang Zhixie Pills combined with Kangfuxin enema on intestinal flora and inflammatory factors in patients with ulcerative colitis and its clinical efficacy.Methods 84 cases of ulcerative colitis admitted to our hospital from were divided into a control group(42 cases)and an observation group(42 cases).Before and after treatment,the Chinese medicine symptoms and quality of life were evaluated by the Chinese medicine syndrome score table and the quality of life score table.At the same time,the intestinal flora index of the patient was detected,and the inflammatory factor level and the patient’s nutrition index were detected by enzyme-linked immunosorbent assay.Finally,record the occurrence of adverse reactions between the two groups during treatment.Results The total effective rate after treatment in the observation group was significantly higher than that in the control group(P<0.05);after treatment,the cured patients in the observation group with a stool cue ratio lower than 1/10 were significantly higher than those in the control group,while the observation group had no significant improvement(Fecal cue ratio>1/6)was significantly lower than the control group(P<0.05).The numbers of anaerobic bacteria and Bacteroides increased significantly after treatment in the two groups(P<0.05),while Escherichia coli and Pseudomonas aeruginosa significantly increased Reduced(P<0.05).The improvement of intestinal flora in the observation group was significantly better than that of the control group(P<0.05);the levels of inflammatory factors(IL-6,IL-17,TNF-α)after treatment in the two groups were lower.The group was significantly lower before treatment(P<0.05),and the observation group was significantly lower than the control group(P<0.05).The QOL scores of the two groups after treatment were higher than those of the group before treatment,and the TCM syndrome scores were lower than those of the group before treatment(P<0.05).The score of TCM syndromes in the observation group was signifi

关 键 词：固肠止泻丸 溃疡性结肠炎 肠道菌群 炎症因子 康复新液 

分 类 号：R574.62[医药卫生—消化系统]