β-肾上腺素能受体在乳腺癌发生发展中的作用  

Role of β-adrenergic receptors in development of breast cancer

作　　者：宋莉 戴小斌 贾琦[1] 周银银 李晓曼 吴媛媛 陈文星[1,2] 王爱云[1,2] 陆茵[1,2] SONG Li;DAI Xiao-bin;JIA Qi;ZHOU Yin-yin;LI Xiao-man;WU Yuan-yuan;CHEN Wen-xing;WANG Ai-yun;LU Yin(Jiangsu Key Lab for Pharmacology and Safety Evaluation of Chinese Materia Medica,School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine(TCM)Prevention and Treatment of Tumor,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室,江苏南京210023 [2]南京中医药大学江苏省中医药防治肿瘤协同创新中心,江苏南京210023

出　　处：《中国药理学通报》2021年第3期309-313,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81961128020,81973587,81973734,81903857);江苏省研究生科研创新计划(No KYCX20_1502)。

摘　　要：β-肾上腺素能受体(β-adrenergic receptors,β-ARs)广泛分布于机体各组织器官中,在调节心脏功能、血管扩张、能量代谢等方面具有重要作用。研究表明,β-ARs在乳腺癌细胞中异常高表达,可通过影响乳腺癌的生长代谢、侵袭转移、血管生成等过程促进乳腺癌的发生和发展。临床研究证实,阻断β-ARs信号传导可改善乳腺癌患者的预后,故β-ARs或可成为治疗乳腺癌的潜在靶点。本文对β-ARs在乳腺癌发生、发展过程中的作用进行综述,为临床治疗及后续研究提供一些参考。β-adrenergic receptors(β-ARs)are widely found in organs of the human body and play an important role in regulating heart function,blood vessel dilation,energy metabolism,etc.Studies have shown thatβ-ARs are abnormally high in breast cancer cells,which can promote the occurrence and development of breast cancer by affecting the growth and metabolism of breast cancer,invasive metastasis,and angiogenesis.Clinical studies have shown that blockingβ-ARs signaling improves the prognosis of breast cancer patients,soβ-ARs may be a potential treatment target for breast cancer.This paper summarizes the role of β-ARs in the development of breast cancer,with a view to providing some reference for follow-up research and clinical treatment.

关 键 词：Β-肾上腺素能受体 乳腺癌 儿茶酚胺 应激 肿瘤发展 Β-肾上腺素能受体阻滞剂 

分 类 号：R364.3[医药卫生—病理学] R392.11[医药卫生—基础医学]