不同运动障碍亚型帕金森病的非运动症状对照研究  

The comparative study of non motor symptoms in different subtypes of Parkinson's disease

作　　者：庞坚信[1] 黄沛钰[2] 王冬女[1] 季文斌[1] 刘素芝[1] Pang Jianxin

机构地区：[1]浙江省台州医院,317000 [2]浙江大学医学院附属第二医院,310009

出　　处：《浙江临床医学》2021年第2期177-178,181,共3页Zhejiang Clinical Medical Journal

基　　金：国家自然科学基金资助项目(81771820);浙江省基础公益基金项目(LGF20H090009)。

摘　　要：目的比较不同运动障碍亚型帕金森病患者的非运动症状评估量表,提高对不同运动障碍亚型帕金森病非运动症状的认识。方法回顾性收集76例帕金森病患者病例资料,按统一帕金森病评估量表(UPDRS)评分分为震颤为主型(TD)组29例和姿势异常步态障碍为主型(PIGD)组47例,比较两组患者简易精神状态蓝测量表(MMSE)评分、蒙特利尔认知量表(MoCA)评分、老年抑郁量表(GDS-15)评分、汉密尔领焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分和便秘临床评分量表(CCS)评分。结果两组患者MMSE、MoCA、GDS-15、HAMA、HAMD和CCS评分差异均存在统计学意义(P<0.05)。结论帕金森病不同运动障碍亚型之间存在不同程度的非运动症状差异,提高对运动障碍亚型的认识利于分组诊治。Objective To compare the rating scale of non motor symptoms in patients with Parkinson's disceasc of diferent motor disorderssubypes, and to improve the recognition of non motor symptoms in patients with Parkinson's disease of dfferent motor disorders subtypes. Methods Atotal of 76 patients with Parkinson's disease were collected retrospectively. According to the Unified Parkinson's disease rating scale ( UPDRS),29patients were divided into temor dominant ( TD ) group and 47 patients were divided into postural instability gait dificulr ( PIGD) group. The scores ofMMSE,MoCA, GDS- 15, HAMA, HAMD and CCS scores were compared between the two groups. Results There were significant differences inMMSE, MoCA, GDS-15,HAMA, HAMD and CCS scores berween the two groups ( P<0.05 ) . Conclusion There are diferent degrees of nonmobor sylmnptoms among diferent motor dysfunc tion subtypes of Parkinson's disease. It is helpful to improve the recognition of motor dysfunction subtypesfor grouping diagnosis and treatment.

关 键 词：帕金森病 震颤 姿势异常步态障碍 运动障碍亚型 

分 类 号：R74[医药卫生—神经病学与精神病学]