超量服用盐酸帕罗西汀致癫痫发作  

Epileptic seizures due to overdose of paroxetine hydrochloride

作　　者：孙振晓[1] 于相芬[1] Sun Zhenxiao;Yu Xiangfen(Department of Psychiatry,Linyi Municipal Mental Health Center,Shandong Province,Linyi 276005,China)

机构地区：[1]山东省临沂市精神卫生中心精神科,临沂276005

出　　处：《药物不良反应杂志》2021年第1期51-52,共2页Adverse Drug Reactions Journal

摘　　要：1例61岁女性抑郁障碍患者医嘱给予盐酸帕罗西汀20 mg每早口服1次,患者误按3次/d服用。服药第6天,患者突然倒地,意识不清,四肢抽搐,呈癫痫样发作。脑电图检查示中度异常。患者既往无癫痫病史及家族史,癫痫发作的原因考虑与超频次服用盐酸帕罗西汀有关。按医嘱正确服药并加用丙戊酸镁缓释片0.25 g、2次/d治疗后,患者未再出现癫痫发作,脑电图恢复正常。A 61‑year‑old female patient with depressive disorder was prescribed paroxetine hydrochloride 20 mg orally once each morning,but the patient took the drug thrice daily by mistake.On the 6th day of medication,the patient suddenly fell down.She was unconscious accompanied by limb convulsion,presenting as epileptic attack.Electroencephalogram(EEG)showed a moderate abnormality.The patient had no previous history or family history of epilepsy,the cause of the seizures was considered to be overdose of paroxetine hydrochloride.The drug was taken correctly as prescribed by doctor and magnesium valproate sustained release tablets 0.25 g orally twice daily were added.The patient did not have any further epileptic attack and the EEG recovered to normal.

关 键 词：帕罗西汀 用药错误 癫痫发作 

分 类 号：R742.1[医药卫生—神经病学与精神病学]