溃疡性结肠炎患者血清总胆红素和尿酸水平与炎性因子的相关性研究  

Correlation Study between Serum Total Bilirubin and Uric Acid Levels and Inflammatory Factors in Patients with Ulcerative Colitis

作　　者：王春莹 焦婕英 张永欢 刘静静 陈振伟[2] 张雅静[3] WANG Chun-ying;JIAO Jie-ying;ZHANG Yong-huan;LIU Jing-jing;CHEN Zhen-wei;ZHANG Ya-jing(Department of Gastroenterology,China Weapons Industry 521 Hospital,Xi'an,Shaanxi,710065,China;Department of Gastrointestinal Surgery,Xi'an High Tech Hospital,Xi'an,Shaanxi,710075,China;Department of Digestive Surgery,Xijing Hospital of the Fourth Military Medical University,Xi'an,Shaanxi,710032,China)

机构地区：[1]中国兵器工业五二一医院消化内科,陕西西安710065 [2]西安高新医院胃肠外科,陕西西安710075 [3]第四军医大学西京医院消化外科,陕西西安710032

出　　处：《现代生物医学进展》2020年第24期4726-4729,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81270849);陕西省卫生计生委科学技术基金项目(2018SF-229)。

摘　　要：目的:探讨溃疡性结肠炎(UC)患者血清总胆红素(STB)和尿酸(UA)与炎症因子之间的相关性。方法:选取2015年6月至2019年5月于我院确诊为UC的患者90例(UC组)和体检中心的健康体检人员90例(对照组)作为研究对象,UC组按Truelove-Witts病情程度分级标准和Mayo评分分组,采用全自动生化仪检测研究对象STB和UA水平,采用酶联免疫吸附试验检测研究对象血清中的肿瘤坏死因子-α(TNF-α)、白介素1β(IL-1β)和白介素6(IL-6)的水平,分析STB和UA水平与血清炎症因子水平、病情严重程度和Mayo评分的关系。结果:STB在UC组的水平低于对照组(P<0.05),UC重度患者STB水平低于轻度、中度患者(P<0.05),STB水平随着病情严重程度和Mayo评分增加而降低(P<0.05);血清UA、TNF-α、IL-1β和IL-6在UC组的水平高于对照组(P<0.05),并且随着病情严重程度和Mayo评分增加而升高(P<0.05);STB水平与炎症因子(TNF-α、IL-1β和IL-6)水平、病情严重程度和Mayo评分均呈负相关(P<0.05),血清UA水平与炎症因子(TNF-α、IL-1β和IL-6)水平、病情严重程度和Mayo评分均呈正相关(P<0.05)。结论:STB和UA在UC患者中异常表达,可能参与了UC的炎性反应过程,二者均与病情有关,可以用来辅助评估UC的病情严重程度。Objective:To explore the correlation of serum total bilirubin(STB)and uric acid(UA)levels and inflammatory factors in patients with ulcerative colitis(UC).Methods:90 cases of patients diagnosed with UC in our hospital(UC group)and 90 cases of healthy physical examination personnel in the physical examination center(control group)from June 2015 to May 2019 were selected as the study subjects.The UC group was grouped according to the truelove-witts disease grade criteria and Mayo score.The STB and UA levels were detected by automatic biochemical instrument.Serum tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and interleukin-6(IL-6)levels were measured by enzyme-linked immunosorbent assay.the relationship between STB and UA levels and serum inflammatory factors levels,disease severity and Mayo score were analyzed.Results:The STB levels in the UC group was lower than that in the control group(P<0.05),the level of STB in severe UC patients was lower than that in mild and moderate UC patients(P<0.05),the level of STB decreased with the disease severity and the increase of the Mayo score(P<0.05).Serum UA,TNF-α,IL-1βand IL-6 levels in the UC group were higher than those in the control group(P<0.05),and increased with the disease severity and the Mayo score(P<0.05).STB levels were negatively correlated with inflammatory factors(TNF-α,IL-1β,and IL-6),severity of disease,and Mayo score(P<0.05),while serum UA levels were positively correlated with inflammatory factors(TNF-α,IL-1β,and IL-6),severity of disease,and Mayo score(P<0.05).Conclusion:STB and UA are abnormally expressed in UC patients,which may be involved in the inflammatory reaction process of UC.Both of them are related to the condition of UC and can be used to assist in the assessment of the severity of UC.

关 键 词：溃疡性结肠炎 总胆红素 尿酸 炎症因子 

分 类 号：R574.62[医药卫生—消化系统]