血清CA72-4、CA199对结直肠癌的诊断价值及与肿瘤进展的关系研究  

Diagnostic Value of Serum CA72-4 and CA199 for Colorectal Cancer and Its Relationship with Tumor Progression

作　　者：杨娟[1] 李亚飞 宋晓燕[1] 袁青玲 赞梅[1] 本巴吉[1] YANG Juan;LI Ya-fei;SONG Xiao-yan;YUAN Qing-ling;ZAN Mei;BEN Ba-ji(Department of Medical Oncology,Qinghai Provincial People's Hospital,Xining,Qinghai,810007,China)

机构地区：[1]青海省人民医院肿瘤内科,青海西宁810007

出　　处：《现代生物医学进展》2020年第24期4743-4746,共4页Progress in Modern Biomedicine

基　　金：青海省科学技术厅研究项目(2015-ZJ-768)。

摘　　要：目的:探讨血清糖类抗原72-4(CA72-4)、糖类抗原199(CA199)对结直肠癌的诊断价值及与肿瘤进展的关系。方法:选取2016年7月到2018年7月期间在我院接受治疗的结直肠癌患者60例作为结直肠癌组,另选取同期在我院接受治疗的结直肠良性病变患者40例作为良性病变组,比较结直肠癌组、良性病变组血清CA72-4、CA199的水平,比较不同TNM分期、不同分化程度的结直肠癌患者血清CA72-4、CA199的水平,以病理诊断为金标准,分析血清CA72-4、CA199对结直肠癌的诊断价值。结果:结直肠癌组的血清CA72-4、CA199水平高于良性病变组(P<0.05)。TNM分期为III-IV期的结直肠癌患者的血清CA72-4、CA199水平高于Ⅰ-Ⅱ期的患者(P<0.05),分化程度为低分化的结直肠癌患者的血清CA72-4、CA199水平高于中高分化的患者(P<0.05)。CA72-4联合CA199检测对结直肠癌的灵敏度高于CA72-4、CA199单独检测。结论:CA72-4与CA199联合检测对结直肠癌具有较高的诊断价值,且两指标的水平与结直肠癌的分化程度和TNM分期有关,可在一定程度上反映肿瘤进展情况。Objective:To investigate the diagnostic value of serum carbohydrate antigen 72-4(CA72-4)and carbohydrate antigen 199(CA199)for colorectal cancer and its relationship with tumor progression.Methods:60 patients with colorectal cancer who were treated in our hospital from July 2016 to July 2018 were enrolled as colorectal cancer group,another 40 patients with benign colorectal lesions who were treated in our hospital at the same time were selected as benign lesion group.The levels of serum CA72-4 and CA199 were compared in colorectal cancer group and benign lesions group.The levels of serum CA72-4 and CA199 in colorectal cancer patients with different TNM stage and differentiation degree were compared.The pathological diagnosis was used as the gold standard,the diagnostic value of serum CA72-4 and CA199 for colorectal cancer were analyzed.Results:The levels of serum CA72-4 and CA199 in the colorectal cancer group were higher than those in the benign lesion group(P<0.05).The levels of serum CA72-4 and CA199 in patients with colorectal cancer with TNM stage Ⅲ-Ⅳ stage were higher than those in the patients with stage Ⅰ-Ⅱ(P<0.05).The levels of serum CA72-4 and CA199 in patients with poorly differentiated colorectal cancer were higher than those in patients with moderately or highly differentiated colorectal cancer(P<0.05).The sensitivity of CA72-4 combined with CA199 detection for colorectal cancer is higher than that of CA72-4 and CA199 alone detection.Conclusion:The CA72-4 combined with CA199 detection has a high diagnostic value for colorectal cancer,and the level of these two indicators is related to the differentiation degree and TNM stage of colorectal cancer,which may reflect the progress of the tumor to some extent.

关 键 词：糖类抗原72-4 糖类抗原199 结直肠癌 诊断 

分 类 号：R735.3[医药卫生—肿瘤]