血管性抑郁患者血清TRPC1水平的变化及意义  

Changes and significance of serum TRPC1 levels in patients with vascular depression

作　　者：沈雷 傅国惠 曹杏[1] SHEN Lei;FU Guohui;CAO Xing(Department of Neurology,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院神经内科三病区,南阳473000

出　　处：《国际精神病学杂志》2020年第6期1171-1174,共4页Journal Of International Psychiatry

摘　　要：目的探讨血管性抑郁患者血清瞬时受体电位通道1(TRPC1)水平的变化及其意义。方法选择本院2016年12月~2019年12月收治的83例血管性抑郁患者作为研究对象,根据汉密尔顿抑郁量表(HAMD)将其分为轻度抑郁组和重度抑郁组,另选择同期的40例健康体检者作为对照组。比较三组不同性别、年龄、蒙特利尔认知功能评估量表(MoCA)的TRPC1。结果根据HAMD评分,重度抑郁组35例,轻度抑郁组48例。重度抑郁组的TRPC1(562.78±69.45)pg/ml,显著低于轻度抑郁组的TRPC1(659.53±84.60)pg/ml和对照组的TRPC1(738.61±95.72)pg/ml,差异均有统计学意义(P<0.05),TRPC1水平与HAMD评分具有负相关关系(P<0.05)。重度抑郁组不同性别、年龄的TRPC1显著低于轻度抑郁组和对照组,重度抑郁组MoCA<21分者、MoCA 21~26分者的TRPC1显著低于轻度抑郁组,(P<0.05);三组MoCA>26分者的TRPC1比较,差异无统计学意义(P>0.05)。结论血管性抑郁患者的TRPC1与抑郁程度有显著相关性,并影响患者的认知功能,临床可通过监测TRPC1水平指导抑郁症的诊断与治疗,并对抑郁症发病、发展及转归进行预测。Objective To analyze the changes and significance of serum transient receptor potential channel 1(TRPC1)levels in patients with vascular depression. Methods Eighty-three patients with vascular depression in our hospital from December 2016 to December 2019 were selected as the research objects. According to the Hamilton depression scale(HAMD),they were divided into low-grade depression group and high-grade depression group,and 40 healthy patients during the same period were selected. The physical examinee served as a control group. TRPC1 of different gender,age,and Montreal cognitive function assessment scale(MoCA)were compared among the three groups. Results According to the HAMD score,there were 35 cases in the high depression group and 48 cases in the low depression group. TRPC1(562.78±69.45)pg/ml in the high-depression group was significantly lower than TRPC1(659.53±84.60)pg/ml in the low-depression group and TRPC1(738.61±95.72)pg/ml in the control group. The differences were statistically significant. Significance(P<0.05),TRPC1 level is negatively correlated with HAMD score(P<0.05). The TRPC1 of different genders and ages in the high-depression group was significantly lower than that of the low-depression group and the control group. The TRPC1 of the high-depression group with MoCA<21 points and MoCA 21~26 points was significantly lower than that of the low-depression group with statistical differences. Significance(P<0.05). There was no significant difference in TRPC1 among the three groups with MoCA>26 points(P>0.05). Conclusion There is a significant correlation between TRPC1 and the degree of depression in patients with vascular depression,and affects patients’ cognitive function. Clinically,monitoring the level of TRPC1 can guide the diagnosis and treatment of depression,and predict the onset,development and outcome of depression.

关 键 词：血管性抑郁 TRPC1 性别 年龄 MOCA 

分 类 号：R749.4[医药卫生—神经病学与精神病学]