艾司西酞普兰联合拉莫三嗪对脑卒中后癫痫共病抑郁患者心理和神经功能的影响  

Effects of escitalopram oxalate combined with lamotrigine on mental state and neurological function in epilepsy comorbid depression patients after stroke

作　　者：朱好春 葛晗明 赵航[3] 张艳华[1] ZHU Haochun;GE Hanming;ZHAO Hang(Department of Neurology,General Hospital of Hebi Coal Industry(Group)Co.,Ltd.Hebi 458030,China)

机构地区：[1]鹤壁煤业(集团)有限责任公司总医院神经内科,鹤壁458030 [2]西北大学附属医院西安市第三人民医院神经内科 [3]西安医学院第一附属医院神经内科

出　　处：《国际精神病学杂志》2020年第6期1175-1177,1180,共4页Journal Of International Psychiatry

摘　　要：目的探讨艾司西酞普兰联合拉莫三嗪对脑卒中后癫痫共病抑郁患者心理及神经功能的影响。方法将我院2018年9月~2019年9月收治的84例脑卒中后癫痫共病抑郁患者根据随机数字表法分为对照组和研究组。对照组41例给予拉莫三嗪治疗,研究组43例加用草酸艾司西酞普兰治疗,治疗12周。对比两组患者治疗前后癫痫发作频率、汉密尔顿抑郁量表(HAMD)、美国卫生院卒中量表(NIHSS)、日常生活活动能力(ADL)和血清神经递质水平:5-羟色胺(5-HT)、神经生长因子(NGF)、脑源性神经营养因子(BDNF)。结果治疗后研究组癫痫发作频率、HAMD、NIHSS评分低于对照组,ADL评分、5-HT、NGF、BDNF水平高于对照组(P<0.05)。结论草酸艾司西酞普兰联合拉莫三嗪治疗脑卒中后癫痫共病抑郁患者,可降低其癫痫发作频率,促进其神经功能恢复,提升患者的日常生活活动能力,有效改善患者的抑郁症状。Objective To investigate the effect of escitalopram oxalate combined with lamotrigine on mental state and nerve function in epilepsy comorbid depression patients after stroke. Methods 84 post-stroke epilepsy patients with depression in our hospital from September 2018 to September 2019 were selected and divided into a control group and a research group according to random number table method.41 cases in the control group were treated with lamotrigine for 12 weeks,and 43 cases in the study group added escitalopram oxalate for 12 weeks. The frequency of seizures,the scores of Hamilton Depression Scale(HAMD),American Hospital Stroke Scale(NIHSS),daily living activity capacity(ADL)and the level serum 5-hydroxytryptamine(5-HT),Nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF)were compared before and after treatment between two groups. Results After treatment,the seizure frequency,HAMD and NIHSS scores in the study group were lower than those in the control group,and the ADL scores,5-HT,NGF,and BDNF levels were higher than those in control group(P<0.05). Conclusion The combination of escitalopram oxalate and lamotrigine can reduce the frequency of seizures,promote the recovery of nerve function,enhance the ability of daily life activities,and effectively improve the symptoms of depression in post-stroke epilepsy patients with depression.

关 键 词：拉莫三嗪 草酸艾司西酞普兰 脑卒中后癫痫 抑郁 

分 类 号：R749.99[医药卫生—神经病学与精神病学]