硫必利联合维生素B12对儿童抽动障碍患者的效果对及其神经功能的影响  

The effect of thiopiride hydrochloride combined with vitamin B12 in children with tic disorder and its effect on their neurological function

作　　者：柳旎 陈振辉[1] 李沫民 张淼[1] LIU Ni;CHEN Zhenhui;LI Momin(Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院,南阳473000 [2]南阳市第二人民医院

出　　处：《国际精神病学杂志》2020年第6期1210-1212,共3页Journal Of International Psychiatry

摘　　要：目的探讨抽动障碍患儿采用硫必利联合维生素B12治疗的效果及对患儿神经功能的影响。方法纳入2017年1月~2018年1月期间将我院接诊的87例抽动障碍患儿作为观察对象,采用掷币法将其分为对照组(43例接受盐酸硫必利治疗)和观察组(44例,接受盐酸硫必利联合维生素B12治疗),比较两组患儿治疗效果及神经功能。结果治疗后,观察组YGTSS评分及兴奋性氨基酸水平明显低于对照组,组间差异明显(P<0.05);观察组ASIA神经功能评分及总有效率均明显高于对照组,组间差异明显(P<0.05)。结论盐酸硫必利联合维生素B12可有效缓解抽动障碍患儿运动性抽动及发声性抽动症状,改善患儿神经功能。Objective To investigate the effect of thiopiride hydrochloride combined with vitamin B12 in the treatment of tic disorders in children and its effect on their neurological function. Methods From January 2017 to January 2018,87 children with tic disorder in our hospital were selected and divided into the control group(43 patients receiving thiopiride hydrochloride)and observation group(44 cases,receiving thiopiride hydrochloride combined with vitamin B12). The treatment effect and neurological function were compared between the two groups. Results After treatment,the YGTSS score and excitatory amino acid levels in the observation group were significantly lower than those in the control group(P<0.05). The ASIA neurological function score and total effective rate in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Thibride hydrochloride combined with vitamins can effectively alleviate the symptoms of motor tics and vocal tics in children with tic disorder,improve the neurological function of children.

关 键 词：盐酸硫必利 维生素B12 抽动障碍 神经功能 

分 类 号：R749.94[医药卫生—神经病学与精神病学]