血清AFP、AFP-L3、HSP90α表达水平在肝细胞癌诊断中的价值  

The value of serum AFP,AFP-L3 and HSP90αin the diagnosis of hepatocellular carcinoma

作　　者：段云[1] 杨颖卓[1] 杨雯 王乔 徐蓉生[1] DUAN Yun;YANG Yingzhuo;YANG Wen;WANG Qiao;XU Rongsheng(Department of Nuclear Medicine,Sichuan Cancer Hospital,Chengdu,Sichuan 610041,China)

机构地区：[1]四川省肿瘤医院核医学科,四川成都610041

出　　处：《国际检验医学杂志》2021年第5期590-593,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨血清中肿瘤标志物甲胎蛋白(AFP)、甲胎蛋白异质体(AFP-L3)及热休克蛋白90a(HSP90α)单独及联合检测在肝细胞癌(HCC)诊断中的临床价值。方法选取2017年1月至2019年10月在该院住院治疗的HCC患者191例(观察组)作为研究对象,另选取同期的肝硬化(LC)患者28例作为对照组。各组血清AFP、AFP-L3、HSP90α进行检测比较,并采用受试者工作特征曲线(ROC曲线)分析其在HCC诊断中的价值。结果对照组天门冬氨酸氨基转移酶、总胆红素水平高于观察组,对照组清蛋白水平低于观察组,差异均有统计学意义(P<0.05);两组肿瘤标志物AFP、AFP-L3、HSP90α水平比较,差异均有统计学意义(P<0.05)。AFP、AFP-L3、HSP90α诊断HCC时,AFP+AFP-L3+HSP90α联合检测诊断能力最佳。AFP-L3是区分HCC早期和LC特异度较高的指标。AFP、AFP-L3、HSP90α水平随着HCC的巴塞罗那临床肝癌分期发展,ROC曲线下面积越大,诊断能力越明显。结论血清AFP、AFP-L3、HSP90α联合检测对HCC的诊断具有较高的临床价值。Objective To investigate the clinical value of alpha-fetoprotein(AFP),alpha-fetoprotein L3(AFP-L3)and heat shock protein 90a(HSP90α)in the diagnosis of hepatocellular carcinoma(HCC).Methods A total of 191 HCC patients(observation group)hospitalized in a hospital from January 2017 to October 2019 were selected as the study subjects,and 28 patients with liver cirrhosis(LC)during the same period were selected as the control group.The serum AFP,AFP-L3 and HSP90αwere detected and compared in each group,and the value of the serum AFP,AFP-L3 and HSP90αin the diagnosis of HCC was analyzed by receiver operating characteristic curve(ROC curve).Results The levels of aspartate aminotransferase and total bilirubin in the control group were higher than those in the observation group,and the albumin levels in the control group were lower than those in the observation group,with statistical significance(P<0.05).There were statistically significant differences in the levels of tumor markers AFP,AFP-L3 and HSP90αbetween the two groups(P<0.05).AFP+AFP-L3+HSP90αhad the best diagnostic ability when AFP,AFP-L3 and HSP90αwere used in the diagnosis of HCC.AFP-L3 was a high specificity index to distinguish early HCC from LC.The levels of AFP,AFP-L3 and HSP90αdeveloped with the stages of barcelona clinic liver cancer of HCC,and the larger the area under the ROC curve,the more obvious the diagnostic ability.Conclusion The combined detection of serum AFP,AFP-L3 and HSP90αhas high clinical value in the diagnosis of HCC.

关 键 词：甲胎蛋白 甲胎蛋白异质体 热休克蛋白90a 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]