雌孕激素与HPV在宫颈癌发生中的交互作用及相关因素研究  

Study on the interaction between estrogen and progesterone and HPV in cervical cancer and its related factors

作　　者：张晓瑜 樊萍[1] ZHANG Xiao-yu;FAN Ping(Department of Obstetrics and Gynecology,Chongqing Fifth People's Hospital,Chongqing 400062,China)

机构地区：[1]重庆市第五人民医院妇产科,重庆400062

出　　处：《川北医学院学报》2021年第2期163-165,共3页Journal of North Sichuan Medical College

基　　金：重庆市卫计委科研项目(2015MSXM109)。

摘　　要：目的:探究雌孕激素与人乳头瘤病毒(HPV)在宫颈癌发生中的交互作用及相关因素。方法:将72例宫颈癌患者设为试验组,选择同时期体检的76名健康者设为对照组。检测两组雌二醇(E2)、孕酮(P)、HPVs和HPV16进行检测并比较,并分析雌孕激素与HPV的相互作用,使用多元Logistic回归分析分析宫颈癌发生中的相关因素。结果:试验组的E2水平、P水平、HPVs阳性率和HPV16阳性率均高于对照组(P<0.05);生物学交互作用的相加作用模式分析结果显示,E2与HPVs呈正相加作用(P<0.05);经Logistic分析结果显示E2和HPV对宫颈癌发生有一定影响,且与宫颈癌的发生呈正相关(P<0.05)。结论:高水平雌激素与HPV感染在宫颈癌发生过程中起协同作用。Objective:To study the interaction and related factors of estrogen and progesterone with human papilloma virus(HPV)in the occurrence of cervical cancer and provide guidance for clinical diagnosis and treatment.Methods:72 cases of cervical cancer patients were selected as the experimental group,and 76 cases of healthy people at the same time were selected as the control group.The estradiol(E2),progesterone(P),HPVs,and HPV16 were detected and compared in two groups of subjects,and the interaction between estrogen and progesterone and HPV was analyzed,and multiple Logistic regression analysis was used to analyze the relevant factors in the occurrence of cervical cancer.Results:The levels of E2,P,HPVs and HPV16 in the test group were significantly higher than those in the control group(P<0.05).The results of the analysis of the additive interaction pattern of biological interactions showed that E2 and HPVs showed a positive additive effect(P<0.05).Logistic analysis showed that E2 and HPV had a certain effect on the occurrence of cervical cancer,and E2 and HPV were positively correlated with the occurrence of cervical cancer(P<0.05).Conclusion:High levels of estrogen and HPV infectionlplay a synergistiroal in the development of cervical cancer.

关 键 词：宫颈癌 雌孕激素 人乳头瘤病毒 交互作用 相关因素 

分 类 号：R737.33[医药卫生—肿瘤]