分析HP感染对不同年龄段人群外周动脉硬化的影响差异  

Effect of HP infection on peripheral arteriosclerosis in different age groups

作　　者：李芸[1] 刘菊华 张欢 王冠[1] 柳弥[1] LI Yun;LIU Ju-hua;ZHANG Huan;WANG Guan;LIU Mi(Department of Health Management Health Management Center,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000;Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610073,Sichuan,China)

机构地区：[1]川北医学院附属医院健康管理中心健康管理研究室,四川南充637000 [2]成都中医药大学附属医院,四川成都610073

出　　处：《川北医学院学报》2021年第2期175-179,共5页Journal of North Sichuan Medical College

基　　金：四川省南充市市校科技战略合作专项(18SXHZ0301);川北医学院附属医院2020年院内基金(2020JC034)。

摘　　要：目的:观察幽门螺杆菌(HP)感染对不同年龄段人群外周动脉硬化指标臂-踝脉搏波传导速度(baPWV)及踝肱指数(ABI)的影响差异。方法:选取2015年1月至2019年7月于本院健康管理中心行早期动脉硬化筛查的人群为研究对象,通过回顾性研究分析,收集符合纳入标准的观察人群体检当日的体重指数(BMI),血压,血脂、血糖、血尿酸、hsCRP及同型半胱氨酸(Hcy)水平,通过baPWV及ABI评估外周动脉僵硬度,C13呼气实验检查HP感染。结果:(1)共25247例人群纳入研究,HP+组男性人群所占百分率、BMI、DBP、TG、VLDL及血尿酸水平均高于HP-人群(P<0.05),HP+组HDL低于HP-人群(P<0.01);(2)各年龄段HP+组baPWV数值均高于HP-组(P<0.01),青年人群HP+组ABI数值高于HP-组(P<0.05),老年人群HP+组ABI数值低于HP-组(P<0.05);(3)在各年龄段中,HP+组baPWV轻度、中度及重度增加人群所占百分率均高于HP-组(P<0.01)。除老年人群HP+组ABI 1度及3度人群所占百分率与HP-组无显著差异外,其余各年龄段HP+组在ABI异常分层中所占的百分率均与HP-组有显著差异(P<0.05);(4)在逐步校正各种影响外周动脉硬化进展的因素后,HP感染均是baPWV及ABI分层的独立危险因素(P<0.01),其中HP感染对青年人群baPWV及ABI分层的影响最大,其OR系数最高。结论:HP感染可加速青年、中年及老年人群的外周动脉硬化进展,对青年人群的影响最大。Objective:To observe the effect of Helicobacter pylori(HP)infection on brachial ankle pulse wave velocity(baPWV)and ankle brachial index(ABI)in different age groups.Methods:The populations who tested for early arteriosclerosis in the health management center of our hospital from January 2015 to July 2019 were enrolled in the study.Through retrospective analysis,the body mass index(BMI),blood pressure,blood lipid,blood glucose,plasma levels of uric acid,hsCRP and homocysteine(Hcy)were collect on the day of physical examination,the peripheral arterial stiffness was assessed by baPWV and ABI,HP infection was checked by C13 breath test.Results:(1)A total of 25,247 cases were included in the study,the percentage of male population,BMI,DBP,TG VLDL and plasma levels of uric acid in HP+group were higher than those of HP-group(P<0.05),HDL in HP+group was lower than that of HP-group(P<0.01).(2)The baPWV value of HP+group was higher than that of HP+group in all ages(P<0.01),ABI value of HP+group was higher than that of HP-group in young people,and ABI value of HP+group was lower than that of HP-group in old people(P<0.05).(3)In all ages,the percentage of mild,moderate and severe increase of baPWV was higher in HP+group than those of HP-group(P<0.01).Except that there was no significant difference between HP+group and HP-group in the percentage of ABI 1 degree and 3 degree in old ages,the percentage of HP+group in ABI abnormal stratification was significantly different from that of HP-group(P<0.05).(4)After adjusted all risk factors of peripheral arteriosclerosis,HP infection was still an independent risk factor of baPWV and ABI stratification(P<0.01),furthermore,the HP infection had the greatest influence on baPWV and ABI stratification in young peoples,and its OR coefficient was the highest.Conclusion:HP infection can accelerate the progress of peripheral arteriosclerosis in young,middle-aged and old people,and has the greatest impact on young people.

关 键 词：臂-踝脉搏波传导速度 踝臂指数 幽门螺杆菌 动脉硬化 年龄 

分 类 号：R743[医药卫生—神经病学与精神病学]