盐酸马尼地平的核磁共振数据解析  

NMR Data Analysis of Manidipine Hydrochloride

作　　者：李玉江[1] 赵伟[1] 郭晓河[1] 陶乐[1] 张祥 张海艳[2] 赵天增[1,2] LI Yu-jiang;ZHAO Wei;GUO Xiao-he;TAO Le;ZHANG Xiang;ZHANG Hai-yan;ZHAO Tian-zeng(High&New Technology Research Center of Henan Academy of Sciences,Zhengzhou 450002,China;Key Laboratory of Natural Products,Henan Academy of Sciences,Zhengzhou 450002,China)

机构地区：[1]河南省科学院高新技术研究中心,河南郑州450002 [2]河南省科学院天然产物重点实验室,河南郑州450002

出　　处：《波谱学杂志》2021年第1期110-117,共8页Chinese Journal of Magnetic Resonance

基　　金：河南省重点研发与推广专项(192102310407).

摘　　要：盐酸马尼地平是第三代合成降压新药.本文利用一维、二维核磁共振(NMR)技术,包括^(1)H NMR、^(13)C NMR DEPT-135、^(1)H-^(1)H NOESY、^(1)H-^(1)H COSY、^(1)H-^(13)C HSQC和^(1)H-^(13)C HMBC,对其^(1)H和^(13)C NMR信号进行了全归属,进一步确证了其分子结构.同时,对其^(1)H NMR和^(13)C NMR谱中一些异常信号进行了讨论.Manidipine hydrochloride is the third generation of new synthetic antihypertensive drugs.The structure of manidipine hydrochloride was confirmed with 1D and 2D nuclear magnetic resonance(NMR)techniques,such as ^(1)H NMR,^(13)C NMR,DEPT-135,^(1)H-^(1)H COSY,^(1)H-^(1)H NOESY,^(1)H-^(13)C HSQC,and ^(1)H-^(13)C HMBC.Some abnormal signals in ^(1)H NMR and ^(13)C NMR spectra were further discussed.

关 键 词：液体核磁共振(NMR) 结构确证 二维核磁共振 盐酸马尼地平 ^(14)N核的四极弛豫 

分 类 号：O656.4[理学—分析化学]