急性胆管炎中血清标志物的研究现状  

Research status of serum markers in acute cholangitis

作　　者：白晓东 李之拓[1] 靳亚杰 曹献启 武凯(综述) 孙海军(审校)[1] BAI Xiaodong;LI Zhituo;JIN Yajie;CAO Xianqi;WU Kai;SUN Haijun(Department of Minimally Invasive Biliary Surgery,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院微创胆道外科,哈尔滨150001

出　　处：《临床与病理杂志》2021年第2期432-437,共6页Journal of Clinical and Pathological Research

摘　　要：急性胆管炎是一种威胁生命的胆道细菌感染,能否及早诊断、评估疾病严重程度直接关系到患者的治疗效果与预后。长期以来对血清中标志物的研究较多,如降钙素原(procalcitonin,PCT)、血清糖类抗原CA19-9(carbohydrate antigen 19-9)、血清前白蛋白(prealbumin,PA)、高迁移率蛋白-1(high mobility group box 1,HMGB1),这些标志物与急性胆管炎病理生理均有密切联系。Aute cholangitis is a life-threatening bacterial infection of the bile duct and the early diagnosis and evaluation of the severity of cholangitis patients are therefore directly related to the treatment response and prognosis.For a long time,there are numbers of studies on serum markers,such as procalcitonin(PCT),serum carbohydrate antigen 19-9(CA19-9),prealbumin(PA)and high mobility group box 1(HMGB1).These markers are closely associated to the pathophysiology of acute cholangitis.This review summarizes the research status of the above markers.

关 键 词：急性胆管炎 降钙素原 血清糖类抗原CA19-9 前白蛋白 高迁移率蛋白-1 

分 类 号：R575.7[医药卫生—消化系统]