局部外用药物治疗皮肤癌的研究进展  

Research progress of topical drugs for skin cancer

作　　者：于慧雯(综述) 柏冰雪(审校)[1] YU Huiwen;BAI Bingxue(Department of Dermatology,Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第二医院皮肤科,哈尔滨150000

出　　处：《临床与病理杂志》2021年第2期466-472,共7页Journal of Clinical and Pathological Research

摘　　要：皮肤癌为皮肤恶性病变的总称,主要包括基底细胞癌、皮肤鳞状细胞癌和恶性黑色素瘤。治疗方法主要包括冷冻、激光、电烧灼、放射治疗、化学药物治疗、局部药物、手术切除等,其中手术切除通常为治疗皮肤癌的理想疗法,但由于病灶数量、大小、部位不定,患者耐受情况不一和疾病复发率问题,在手术方案的选择上具有一定的限制性。局部外用药物治疗能使肿瘤部位的药物水平升高,可用于多发性或大面积皮损,同时与全身药物相比具有更小的潜在毒性,是目前治疗皮肤癌的研究热点。Skin cancer is the general term for malignant lesions of the skin,mainly including basal cell carcinoma,squamous cell carcinoma of the skin and malignant melanoma.Treatment mainly includes freezing,laser,electric cauterization,radiation and chemotherapy,local medication,surgery,etc.,and surgical resection for the treatment of skin cancer is usually regarded as an ideal therapy.However,because the quantity of lesion,size,site and patient tolerance is different combined with the potential disease recurrence problem,the choice of operation scheme has certain restriction.Topical drug therapy can increase the drug level at the tumor site,which can be used for multiple or large skin lesions,and has less potential toxicity compared with systemic drugs.Therefore,it is a research hotspot in the treatment of skin cancer.

关 键 词：局部治疗 基底细胞癌 鳞状细胞癌 黑色素瘤 

分 类 号：R73[医药卫生—肿瘤]