中医体质类型与缺血性脑卒中相关性研究的Meta分析  

A Meta-analysis of research on the correlation between TCM constitution types and ischemic stroke

作　　者：郭小妹[1] 刘迎春[1] 杨绮云[1] 王芹[1] 李智[1] 万丽[1] 吴晓霞[1] 董丽娟[1] Guo Xiaomei(不详)

机构地区：[1]中山市中医院,广东中山528400

出　　处：《中医临床研究》2021年第1期129-133,共5页Clinical Journal Of Chinese Medicine

摘　　要：目的:总结有关中医体质类型与缺血性脑卒中相关性研究的现状,探讨缺血性脑卒中患者的中医体质分布规律,为缺血性脑卒中的中医药防治提供循证医学证据。方法:利用计算机检索中国知网、中国维普全文数据库、万方数据、PubMed、Cochrane Library、EMBASE数据库,根据纳入排除标准检索出所有评价中医体质类型缺血性脑卒中相关性的临床研究文献。采用Review Manager 5.3软件进行有对照数据的Meta分析,并以比值比(Odds Ratio,OR)及其95%可信区间(Confidence Interval,CI)表达效应值。结果:最终纳入文献6篇,均为横断面调查研究。样本量总计19060例,其中脑卒中患者1067例,对照组17993例。痰湿质、血瘀质占脑卒中患者的比例分别为17.71%(8.95%,24.50%)、13.78%(6%,34.27%)。Meta分析发现,缺血性脑卒中患者为痰湿型体质、血瘀型体质的发病风险的OR值分别为2.43(95%CI:1.50,3.92),1.72(95%CI:1.34,2.21)。而平和型体质是缺血性脑卒中发病的保护性因素(OR=0.14,95%CI:0.05,0.44)。结论:痰湿质、血瘀质是导致缺血性脑卒中发病的危险因素,其中以痰湿质与缺血性脑卒中的关系最为密切。今后仍需多中心大样本研究,提高研究质量,为未来中医药防治脑卒中提供参考证据。Objective:According to summarize the study on the correlation between TCM constitution types and ischemic stroke,distribution rules of TCM constitution types in patients with ischemic stroke were explored in this article,in order to provide evidencebased medical evidence for prevention and treatment of ischemic stroke in TCM.Methods:All clinical research literatures on evaluating the correlation between TCM constitution types and ischemic stroke in CNKI,VIP,Wanfang database,PubMed,Cochrane Library and Embase data base were retrieved by computer according to the inclusion and exclusion criteria.A Meta-analysis of controlled data was performed in Review Manager 5.3 software,and the effect value was expressed by odds ratio and its 95%confidence interval.Results:Finally,6 studies were included,all of which were cross-sectional surveys.The total sample size was 19060 cases,including 1067 stroke patients and 17993 cases in the control group.Phlegm-damp type and blood-stasis type accounted for 17.71%(8.95%,24.50%)and 13.78%(6%,34.27%)of patients,respectively.The results of Meta-analysis showed that the OR values of the risk of phlegm-damp type and blood-stasis type in patients with ischemic stoke were 2.43(95%CI:1.50,3.92)and 1.72(95%CI:1.34,2.21).The balanced type was a protective factor in the onset of ischemic stoke(OR=0.14,95%CI:0.05,0.44).Conclusion:Phlegm-damp type and blood-stasis type are the risk factors for ischemic stroke.Among them,phlegm-dampness is the most closely related to ischemic stroke.In the future,multi-center and large-sample studies are still needed to improve the research quality and provide reference evidence for the prevention and treatment of stroke in TCM in the future.

关 键 词：中医体质 脑卒中 相关性 系统评价 META分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]