胃肠胰神经内分泌肿瘤肝转移的非手术治疗进展  

Advance in non-surgical treatments for liver metastasis of gastroenteropancreatic neuroendocrine neoplasms

作　　者：胡平[1] 汤琪云[1] HU Ping;TANG Qiyun(Department of Geriatric Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院老年消化科,江苏南京210029

出　　处：《胃肠病学和肝病学杂志》2021年第2期212-216,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：神经内分泌肿瘤(neuroendocrine neoplasms,NENs)肝转移临床常见,手术切除是主要的治疗手段。对于不可手术切除的肝转移患者可采用生长抑素类似物、干扰素、靶向治疗、化疗、介入治疗、肽受体放射性核素治疗等多种全身或局部治疗方法。近期研究表明,索凡替尼为非胰腺NENs的管理提供了新的选择,免疫治疗有望成为晚期NENs治疗的新方向。本文通过回顾相关文献,对胃肠胰NENs肝转移的非手术治疗方法作一概述,为晚期NENs的多学科管理提供参考。Liver metastasis of neuroendocrine neoplasms(NENs)is very common and surgical intervention remains the main treatment nowadays.Somatostatin analogs,interferon,targeted therapy,chemotherapy,interventional therapy,peptide radioreceptor therapy may be applied to those with unresectable lesions.Surufatinib provides a new option for the management of non-pancreatic NENs according to the recent studies and immunotherapy is promising to be a new therapy of advanced NENs in the future.In this study,we reviewed the non-surgical treatments for liver metastasis of gastroenteropancreatic NENs with aim to provide advice for the multidisciplinary management of advanced NENs.

关 键 词：胃肠胰神经内分泌肿瘤 肝转移 非手术治疗 索凡替尼 免疫治疗 

分 类 号：R57[医药卫生—消化系统] R739.4[医药卫生—内科学]